摘要
目的观察表柔比星联合甘露聚糖肽膀胱灌注对非肌层浸润性膀胱癌(NMIBC)术后复发的预防作用。方法将76例NMIBC患者随机分为对照组与观察组(各38例),两组术后均给予表柔比星肽膀胱灌注治疗,观察组在此基础上联合甘露聚糖肽治疗,比较两组术后不良反应、复发率及生活质量的差异。结果观察组患者术后灌注不良反应发生率低于对照组(P<0.01);随访2年,观察组1年和2年复发率均低于对照组(P<0.05),生理健康和心理健康评分均高于对照组(P<0.05或P<0.01)。结论表柔比星联合甘露聚糖肽膀胱灌注可减少NMIBC术后不良反应,预防术后复发,提高患者生活质量。
Objective To observe the preventive effect of the bladder instillation with epirubicin and mannatide in postopera- tive recurrence of non muscle invasive bladder cancer（NMIBC）. Methods After operation,76 cases of NMIBC were randomly divided into control group and treatment group （each 38 cases）, respectively treated with epirubicin and epirubicin plus mannatide intravesical therapy. Quality of life, recurrence rate and adverse reactions of two groups were compared. Results Compared with the control group, the adverse reaction of the treatment group was significantly decreased（P 〈 0.01 ）, the recurrence rate significantly reduced in 2 years （P 〈 0. 05 ）, and the SF-36 scale score was significantly higher（P 〈 0. 05 or P 〈 0. 01 ）. Conclusion For patients with NMIBC, bladder instillation with epirubicin and mannatide can reduce the postoperative adverse reaction, and prevent the postoperative recurrence and improve the quality of life.
出处
《白求恩医学杂志》
2016年第6期685-686,共2页
Journal of Bethune Medical Science
关键词
非肌层浸润性膀胱癌
表柔比星
甘露聚糖肽
膀胱灌注
复发
Non muscle invasive bladder cancer, NMIBC
Epirubicin
Mannatide
Bladder instillation
Recurrence
