摘要
目的:探讨尿常规分析对系统性红斑狼疮(SLE)合并尿路感染(UTI)的临床诊断价值。方法:选取SLE患者116例,根据是否合并UTI分为感染组(46例)和无感染组(70例),收集所有患者年龄、性别、中段尿培养结果、尿常规、C反应蛋白(CRP)、SLE活动指数(SLEDAI)结果,分析尿定量和定性指标对SLE合并UTI的诊断价值。结果:女性UTI发病率高于男性,差异有统计学意义(P<0.05)。46例感染患者共检出49株病原菌,其中G-菌35株,占71.43%,G^(+)菌7株,占14.29%,真菌7株,占14.29%。UTI患者临床表现以膀胱刺激症和发热为主。细菌计数预测SLE合并UTI患者的AUC为0.800(0.709~0.891),最佳截断值为242.0个/μL,WBC计数预测SLE患者合并UTI的AUC为0.690(0.590~0.790),最佳截断值为26.0个/μL,联合细菌计数和白细胞(WBC)计数预测SLE患者合并UTI的AUC为0.862(0.784~0.940),AUC_(联合法)>AUC_(细菌计数)>AUC_(WBC计数),差异均有统计学意义(均P<0.05)。CRP与细菌计数、WBC计数、白细胞酯酶均呈正相关,SLEDAI与尿微量白蛋白/尿肌酐比值呈正相关。结论:SLE合并UTI发病率较高,尿常规部分指标对UTI有较高的预测价值。
Objective:To investigate the clinical diagnostic value of routine urine analysis in systemic lupus erythematosus(SLE)complicated with urinary tract infection(UTI).Methods:A total of 116SLE patients diagnosed and treated in our hospital were divided into infection group(46cases)and non infection group(70cases)according to whether they were complicated with UTI.The age,gender,midstream urine culture results,urine routine,C-reactive protein(CRP)and SLE activity index(SLEDAI)results of all patients were collected,and the diagnostic value of urine quantitative and qualitative indicators for SLE complicated with UTI was analyzed.Results:The incidence of UTI in female patients was higher than that in males,and the difference was statistically significant(P<0.05).A total of 49strains of pathogens were detected in 46SLE patients,including 35strains of Gbacteria(71.43%),7strains of G^(+)bacteria(14.29%)and 7strains of fungi(14.29%).The main clinical manifestations were bladder irritation and fever.The AUC of bacterial count in predicting UTI in SLE patients was 0.800(0.709-0.891),and the best cutoff value was 242.0/μL.The AUC of WBC count in predicting UTI in SLE patients was 0.690(0.590-0.790),and the best cutoff value was 26.0/μL.The AUC of combined bacterial count and WBC count in predicting UTI in SLE patients was 0.862(0.784-0.940).AUC_(combined method)>AUC_(bacterial count)>AUC_(WBC count),the difference was statistically significant(all P<0.05).CRP was positively correlated with bacterial count,WBC count and leukocyte,SLEDAI was positively correlated with ACR.Conclusion:The incidence rate of SLE combined with UTI is higher,some indexes of urine routine test might have high predictive value for UTI.
作者
黄波
张静
HUANG Bo;ZHANG Jing(Taihe Hospital of Traditional Chinese medicine,Fuyang,236600,China)
出处
《临床血液学杂志》
CAS
2022年第4期287-290,共4页
Journal of Clinical Hematology
关键词
尿常规
系统性红斑狼疮
尿路感染
白细胞计数
细菌计数
urine routine
systemic lupus erythematosus
urinary tract infection
white blood cell count
bacterial count
