摘要
牛磺酸上调基因1(taurine upregulated 1,TUG1)是一种长链非编码RNA(long non-coding RNA,lncRNA),其通过复杂的分子机制参与骨肉瘤的发生发展。TUG1通过抑制多种miroRNA(miRNA)和调节相关信号通路,促进骨肉瘤细胞的增殖、侵袭和转移,抑制骨肉瘤细胞的凋亡。此外,TUC1的表达水平与骨肉瘤患者的预后相关,是一种判断预后的潜在生物标志物。本文旨在总结近年来的相关研究,对TUG1参与骨肉瘤细胞增殖、凋亡、侵袭和转移的相关分子机制以及TUGI在骨肉瘤中的临床意义的研究进展做--综述。
Taurine upregulated gene 1(TUG1)is a long non-coding RNA(IncRNA),which involves in the occurrence and development of osteosarcoma by complex molecular mechanisms.It can promote the proliferation,invasion and metastasis,and inhibit the apoptosis of osteosarcoma cells by inhibiting some miroRNAs(miRNAs)and regulating related signal pathways.In addition,the expression level of TUG1 is related to the prognosis of osteosarcoma,therefore,TUG1 is a potential biomarker for prognosis.In this paper,by summarizing related studies in recent years,we review the molecular mechanisms of proliferation,apoptosis,invasion and metastasis in osteosarcoma cell mediated by TUG1 and the clinical value of TUG 1 in osteosarcoma.
作者
移穷
刘众成
路凡
夏亚一
YI Qiong;LIU Zhong-cheng;LU Fan;XIA Ya-yi(Department of Orthopaedics,The Second Hospital,Lanzhou University,Lanzhou 730030,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2022年第9期806-809,共4页
Orthopedic Journal of China
