摘要
精神分裂症是一种常见的重性精神障碍,发病机制未明。近年来,越来越多的证据表明精神分裂症与炎症以及色氨酸犬尿氨酸代谢通路之间存在联系。色氨酸代谢产物犬尿酸是N-甲基-D-天门冬氨酸受体(NMDAR)的内源性拮抗剂。在炎症作用下,偏向犬尿酸生成的色氨酸犬尿氨酸代谢失衡会导致NMDAR失能,这可能是精神分裂症的发病机制之一。因此,色氨酸犬尿氨酸代谢通路和炎症可以作为药物靶点,应用在精神分裂症的治疗过程中。现从色氨酸犬尿氨酸代谢通路入手,探讨炎症对犬尿氨酸代谢的影响,总结以此为靶向的药物疗效,呈现色氨酸犬尿氨酸代谢通路失调与炎症在精神分裂症中的研究进展。
Schizophrenia is a severe mental disease with unclear pathophysiology.In recent years,there has been growing evidence showed that schizophrenia was associated with inflammation and tryptophankynurenine pathway.Kynurenic acid,the bioactive metabolite of tryptophan,is an endogenous antagonist of N-methyl-D-aspartic acid receptor(NMDAR).The abnormalities of tryptophan-kynurenine metabolism with inflammatory may lead to the disability of NMDAR,which may be one of the pathogenesis of schizophrenia.Therefore,tryptophan-kynurenine metabolic pathway and inflammation can be used as drug targets for the treatment of schizophrenia.This review discusses the tryptophan-kynurenine metabolic pathway,the effect of inflammation on kynurenine metabolism in schizophrenia,the drug treatment effect targeting kynurenine pathway and inflammation,and summarizes the research progress of tryptophan-kynurenine pathway and inflammatory in schizophrenia.
作者
赵泽欣
郭茜
刘晓华
李冠军
Zhao Zexin;Guo Qian;Liu Xiaohua;Li Guanjun(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)
出处
《神经疾病与精神卫生》
2022年第5期305-310,共6页
Journal of Neuroscience and Mental Health
基金
上海市公共卫生体系建设三年行动计划(2020—2022年)优秀人才培养计划(GWV-10.2-YQ44)
上海市精神心理疾病临床医学研究中心科研计划项目(19MC1911100)。
关键词
犬尿氨酸
精神分裂症
犬尿酸
炎症
综述
Kynurenine
Schizophrenia
Kynurenic acid
Inflammation
Review
