摘要
抑郁症是全世界最常见的精神疾病,氯胺酮作为新型抗抑郁药物,其快速抗抑郁作用与传统抗抑郁药明显延迟的治疗效果形成鲜明对比,但伴随的严重副作用如分离效应等影响了它在临床上的广泛应用。因此,深入了解氯胺酮的作用机制有利于开发更安全有效的新型抗抑郁药物。它的抗抑郁作用机制主要与N-甲基-D-天门冬氨酸受体(NMDA)、α-氨基-3-羟基-5-甲基-4-异[口恶]唑丙酸(AMPA)受体、脑源性神经营养因子(BDNF)、哺乳动物雷帕霉素靶蛋白(mTOR)、GSK-3、炎症因子等信号通路有关,笔者将对其可能作用的相关信号传导通路进行论述,以期找到更安全、更方便使用的氯胺酮替代品。
Depression is the most common mental illness in the world.Ketamine exerts rapid antidepressant action in contrast with the delayed effect of current antidepressant drugs.However,widespread use of ketamine is restricted by its adverse reactions such as dissociative effects.Unraveling the mechanism of ketamine can contribute to develop new and novel pharmacotherapies.Its antidepressant effect is mainly related to NMDA receptors,AMPA receptors,BDNF,mTOR,GSK-3,inflammatory factors and other signaling pathways.The relevant signaling pathways for antidepressant action were reviewed to find safer and more convenient substitutes of ketamine.
作者
秦瑜
宋文悦
梁泽怀
高明奇
QIN Yu;SONG Wen-yue;LIANG Ze-huai;GAO Ming-qi(School of Pharmacy,China Medical University,Shenyang 110000,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2021年第22期1791-1795,共5页
Chinese Pharmaceutical Journal
