摘要
抗N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor, NMDAR)脑炎是一种免疫介导的神经炎性疾病。其特征是复杂的神经精神综合征和存在针对NMDAR的GluN1亚基(glutamate receptor 1)的脑脊液抗体。近年来越来越多报道显示畸胎瘤与抗NMADR脑炎关联密切,且畸胎瘤相关的抗NMADR脑炎,疾病进展快,病情重,早期给予免疫治疗及手术治疗可改善预后。因此本文就抗NMADR脑炎合并卵巢畸胎瘤的流行病学、发病机制、诊治进展进行讨论,以期为医生及研究者们提供参考。
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an immune-mediated inflammatory disease, which is characterized by a complex neuropsychiatric syndrome and the presence of cerebrospinal fluid antibodies against the GluN1 subunit of the NMDAR. Recently, more and more reports have shown that teratoma is closely related to anti-NMADR encephalitis, and ovarian teratoma-related anti-NMDAR encephalitis is more likely to have a rapid progression and more severe. Most patients can get a good prognosis after early immunotherapy and surgery. This article reviews the epidemiology, pathogenesis, diagnosis and treatments of the disease in order to provide reference for doctors and researchers.
出处
《临床医学进展》
2022年第4期2735-2739,共5页
Advances in Clinical Medicine