摘要
目的:探究妊娠期糖尿病(GDM)孕妇血糖控制水平与不良妊娠结局。方法:选取2017年1月-2019年12月本院诊断的GDM孕妇180例临床资料,根据孕期血糖控制水平分为良好组(n=84)与不良组(n=96),产前健康检查正常孕妇90例为对照组。分析3组产妇妊娠及新生儿结局,分析GDM血糖控制水平与不良妊娠结局相关性。结果:GDM孕妇血糖控制不良组发生妊娠高血压、早产、羊水过多、剖宫产、胎膜早破、妊娠肝内胆汁淤积症比例高于血糖控制良好组及对照组(P<0.05),产后出血、产后感染的发生率3组无差异(P>0.05);血糖控制不良组围产儿胎儿窒息、胎儿窘迫、巨大儿、发育受限、新生儿窒息、新生儿低血糖、新生儿高胆红素血症、低体重新生儿、新生儿肺炎及新生儿红细胞增多症的发病率高于血糖控制良好组和对照组(P<0.05),3组围产儿死胎、新生儿畸形的发生率无差异(P>0.05)。多因素logistic逐步回归分析显示,GDM孕妇中,与血糖控制良好组比较,血糖控制不良将增加胎膜早破(1.214倍)、妊娠肝内胆汁淤积症(3.046倍)、早产(1.178倍)、巨大儿(7.267倍)、发育受限(1.219倍)、新生儿低血糖(3.057倍)的风险。结论:GDM孕妇血糖控制不良将导致不良妊娠结局及不良围产儿结局风险增加。
Objective:To explore the relationship between the levels of blood glucose control of pregnant women with gestational diabetes mellitus(GDM)and their pregnancy outcomes.Methods:180 pregnant women with GDM were selected and were divided into group A(84 with good blood glucose control)and group B(96 women with bad blood glucose control)according to the blood glucose control situation of the women during whole pregnancy.And 90 healthy pregnant women were selected in group C.The pregnancy and neonatal outcomes of the women in the three groups were recorded,and the correlation between blood glucose control level of the women with GDM and their pregnancy outcomes was analyzed.Results:The incidences of pregnancy-induced hypertension,premature delivery,polyhydramnios,cesarean section,premature rupture of membranes,and intrahepatic cholestasis of pregnancy of the women in group B were significantly higher than those of the women in group A and in group C(P<0.05),and there were no significant differences in the incidences of postpartum hemorrhage and postpartum infection of the women among the three groups(P>0.05).The incidences of perinatal fetal asphyxia,fetal distress,macrosomia,fetal growth restriction,neonatal asphyxia,neonatal hypoglycemia,neonatal bilirubin levels,high or low birth weight of newborns,neonatal pneumonia,and neonatal polycythemia disease of the women in group B were significantly higher than those of the women in group A and group C(P<0.05),there were no significant differences in the incidences of perinatal stillbirth and the birth defects among the three groups(P>0.05).Multivariate logistic stepwise regression analysis showed that in pregnant women with GDM,the rate of premature rupture of membrane in group B was 1.214 times higher than that in group A,the rate of intrahepatic cholestasis of pregnancy in group B was 3.046 times higher than that in group A,the rate of premature delivery in group B was 1.178 times higher than that in group A,the rate of macrosomia in group B was 7.267 times higher than
作者
徐蕾
赵亭亭
应祝
XU Lei;ZHAO Tingting;YING Zhu(Nanjing Maternal and Child Health Care Hospital,Nanjing,Jiangsu Province,210000)
出处
《中国计划生育学杂志》
2022年第3期681-685,共5页
Chinese Journal of Family Planning
关键词
妊娠期糖尿病
血糖控制水平
不良妊娠结局
不良围产儿
发生风险
Gestational diabetes mellitus
Blood glucose control level
Adverse pregnancy outcomes
Adverse perinatal outcomes
Risk of occurrence
