摘要
在缺血性脑卒中(IS)发生后,以基质金属蛋白酶(MMP)9为核心成员的MMP家族被激活。然而,遗传因素在IS发病过程中发挥了重要作用,其中以MMP-9基因rs3918242多态性研究较为广泛。由于rs3918242位点C与T等位基因发生相互转变,IS患者疾病易感性和出血转化等发生率不尽相同。随着多态性位点检测技术的发展,广大研究者立足于对rs3918242多态性研究进行追踪,以期能寻找一些病因学证据,在临床工作中提升对IS的诊治水平。未来若能将多态性位点检测纳入常规检测,将能更好地预防IS。
The matrix metalloproteinase(MMP)family,of which MMP-9 is a core member,is activated after the onset of ischemic stroke(IS).However,genetic factors play an important role in the pathogenesis of IS,with the rs3918242 polymorphism of the MMP-9 gene being more widely studied.The reciprocal transformation of the C and T alleles at the rs3918242 locus results in a variable incidence of disease susceptibility and hemorrhagic transformation in IS patients.With the development of polymorphic locus detection technology,researchers have been tracking rs3918242 polymorphism studies in order to discover some etiological evidence to improve the efficient diagnosis and treatment of IS in clinical work.The inclusion of polymorphic loci testing in routine testing in the future will contribute to a better prevention of IS.
作者
马宾
李华欣
袁梅
MA Bin;LI Huaxin;YUAN Mei(Department of Neurology,the Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,China)
出处
《医学综述》
CAS
2022年第8期1485-1490,共6页
Medical Recapitulate
基金
国家自然科学基金(81801160)
湖南省科技创新重点工程项目(2020SK1012-3)
湖南省卫生健康委员会课题(202203072849)
湖南省教育科学“十四五”规划课题(XJK21CXL001)。
