摘要
目的:观察补肾活血化痰法治疗缺血性卒中脑动脉狭窄患者临床疗效及对患者基质金属蛋白酶-9 (MMP-9)及基质金属蛋白酶抑制剂-1 (TIMP-1)的影响。方法:选择85例缺血性卒中脑动脉狭窄患者,按随机数字表法分为对照组42例和观察组43例。对照组口服阿托伐他汀钙片和阿司匹林肠溶片治疗,观察组在对照组基础上给予补肾活血化痰法治疗。2组疗程均为8周。比较2组临床疗效,治疗前后日常生活活动能力(ADL)评分、血管狭窄率、血清MMP-9和TIMP-1水平变化。结果:观察组临床总有效率为90.70%,显著高于对照组的69.05%(P <0.05)。治疗前,2组ADL评分比较,差异无统计学意义(P> 0.05)。治疗后,2组ADL评分较治疗前升高(P <0.05),且观察组ADL评分高于对照组(P <0.05)。2组血管狭窄率比较,差异无统计学意义(P> 0.05)。治疗后,2组血管狭窄率较治疗前降低(P <0.05),且观察组血管狭窄率低于对照组(P <0.05)。治疗前,2组血清MMP-9和TIMP-1水平比较,差异无统计学意义(P> 0.05)。治疗后,2组血清MMP-9水平较治疗前降低,TIMP-1水平较治疗前升高;且观察组血清MMP-9水平低于对照组,TIMP-1水平高于对照组;差异均有统计学意义(P <0.05)。结论:补肾活血化痰法治疗缺血性卒中脑动脉狭窄患者临床疗效明显,可降低MMP-9水平而提高TIMP-1水平,值得临床借鉴。
Objective:To observe the clinical effect of the method of tonifying the kidney,activating blood and resolving phlegm for patients with ischemic stroke due to cerebral artery stenosis and its effect on matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1). Methods: A total of 85 cases of patients with ischemic stroke due to cerebral artery stenosis were divided into the control group and the observation group according to the random number table method,42 and 43 cases in each group respectively. The control group was given oral administration of atorvastatin calcium tablets and aspirin enteric-coated tablets,and the observation group was additionally treated with the method of tonifying the kidney,activating blood and resolving phlegm based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effect as well as the changes of the scores of activities of daily living(ADL),the rates of vascular stenosis,the levels of MMP-9 and TIMP-1 in serum before and after treatment in the two groups were compared. Results:The total clinical effective rate was 90.70% in the observation group,significantly higher than that of 69.05% in the control group(P <0.05). Before treatment,there was no significant difference being found in the comparison of the scores of ADL in the two groups(P > 0.05). After treatment,the scores of ADL in the two groups were increased when compared with those before treatment(P < 0.05),and the one in the observation group was higher than that in the control group(P < 0.05). There was no significant difference being found in the comparison of the rates of vascular stenosis in the two groups(P > 0.05). After treatment,the rates of vascular stenosis in the two groups were decreased when compared with those before treatment(P <0.05),and the one in the observation group was lower than that in the control group(P < 0.05). Before treatment,there was no significant difference being found in the comparison of the levels of MMP-9 and TIMP-1 in se
出处
《新中医》
CAS
2019年第7期119-122,共4页
New Chinese Medicine
关键词
缺血性卒中脑动脉狭窄
补肾活血化痰法
基质金属蛋白酶-9
(MMP-9
)
基质金属蛋白酶抑制剂-1
(TIMP-1)
Ischemic stroke due to cerebral artery stenosis
Method of tonifying the kidney, activating blood and resolving phlegm
Matrix metalloproteinase-9(MMP-9)
Tissue inhibitor of metalloproteinase-1 (TIM P-1)
