摘要
目的:探讨氨溴索肺泡灌洗术对重症小叶性肺炎患儿炎症反应的影响。方法:选取2019年5月-2021年5月佛山市妇幼保健院收治的112例重症小叶性肺炎患儿,按照系统分组法随机分为对照组(n=56)和观察组(n=56)。对照组患儿予以常规肺泡灌洗术治疗,观察组患儿则予以盐酸氨溴索联合肺泡灌洗术治疗。比较两组疗效、血气指标[氧合指数(PaO_(2)/FiO_(2))、氧分压(PaO_(2))及二氧化碳分压(PaCO_(2))]、炎症因子[超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞(WBC)]。结果:观察组总有效率为96.43%,高于对照组的85.71%,差异有统计学意义(P<0.05)。治疗后,两组PaO_(2)/FiO_(2)、PaO_(2)均高于治疗前,PaCO_(2)均低于治疗前,观察组PaO_(2)/FiO_(2)、PaO_(2)均高于对照组,PaCO_(2)低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组hs-CRP、PCT、WBC水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:采用氨溴索联合肺泡灌洗术对重症小叶性肺炎患儿进行治疗,能够显著改善患儿血气指标,降低机体炎症反应水平,提高治疗效果,值得推广。
Objective:To explore the effect of Ambroxol alveolar lavage on inflammatory response in children with severe lobular pneumonia.Method:A total of 112 children with severe lobular pneumonia admitted to Maternity and Child Health Hospital of Foshan City from May 2019 to May 2021 were selected,they were randomly divided into control group(n=56)and observation group(n=56)according to the systematic grouping method.The control group was treated with conventional bronchoscopic alveolar lavage,while the observation group was treated with Ambroxol Hydrochloride combined with alveolar lavage.Efficacy,blood gas indexes[oxygenation index(PaO_(2)/FiO_(2)),partial oxygen pressure(PaO_(2))and partial carbon dioxide pressure(PaCO_(2))],inflammatory factors[hs-CRP,procalcitonin(PCT),white blood cell(WBC)]were compared between two groups.Result:The total effective rate of the observation group was 96.43%,which was higher than 85.71%of the control group,the difference was statistically significant(P<0.05).After treatment,PaO_(2)/FiO_(2)and PaO_(2)of both groups were higher than those before treatment,PaCO_(2)of both groups were lower than those before treatment,PaO_(2)/FiO_(2)and PaO_(2)of the observation group were higher than those of the control group,PaCO_(2)of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,PCT and WBC of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Ambroxol combined with alveolar lavage in the treatment of children with severe lobular pneumonia can significantly improve the blood gas index of children,reduce the level of inflammatory reaction and improve the treatment effect,which is worthy of promotion.
作者
黄殷
潘志伟
阳池娇
张玉慧
HUANG Yin;PAN Zhiwei;YANG Chijiao;ZHANG Yuhui(Maternity and Child Health Hospital of Foshan City,Guangdong Province,Foshan 528000,China;不详)
出处
《中国医学创新》
CAS
2022年第11期37-40,共4页
Medical Innovation of China
基金
佛山市卫生健康局医学科研课题立项项目(20200002)。
关键词
重症小叶性肺炎
肺泡灌洗术
氨溴索
炎症反应
血气指标
Severe lobular pneumonia
Alveolar lavage
Ambroxol
Inflammatory response
Blood gas index
