摘要
目的了解南京地区健康儿童血清脂溶性维生素A、D、E的水平。方法收集南京医科大学第二附属医院健康儿童的体检资料并分组,每例儿童血清维生素A(VA)、维生素E(VE)水平采用反相高效液相色谱荧光检测法测定,每例儿童血清25羟维生素D(25-OH-VD)水平采用液相串联质谱法测定,分析各年龄组维生素A、D、E的水平。结果健康体检儿童共2151例,血清VA平均水平为(0.32±0.08)mg/L,≤1岁组VA水平最低(0.29±0.075)mg/L;所有受检儿童低水平VA检出率为37.09%,≤1岁组检出率最高(54.19%);血清25-OHVD平均水平(34.24±9.31)μg/L,>6岁组25-OH-VD水平最低(25.58±8.67)μg/L;所有受检者低水平25-OH-VD检出率为33.56%(722/2151),>6岁组检出率最高(77.89%);血清VE平均水平为(10.69±3.57)mg/L,>6岁组最低(8.59±1.96)mg/L;所有受检者低水平VE检出率为5.57%(120/2151),>6岁组检出率最高(20%)。男童血清25-OH-VD和VE水平低于女童。6岁<年龄≤14岁组的男童血清25-OH-VD水平比女童低(P=0.043)。≤1岁组和1岁<年龄≤3岁组男童血清VE的水平低于同年龄段女童(P<0.05)。结论南京地区1岁以下儿童VA水平最低,25-OH-VD、VE水平则随儿童年龄增长,逐渐降低。
Objective To investigate the levels of serum soluble vitamins A,D,and E in healthy children in Nanjing.Methods The data of physical examination of healthy children in the Second Affiliated Hospital of Nanjing Medical University were collected and grouped.The levels of serum vitamin A and vitamin E of each child were determined by reversed-phase high-performance liquid chromatography fluorescence detection.The levels of serum 25-hydroxy vitamin D(25(OH)D)were determined by liquid phase tandem mass spectrometry,and the levels of vitamins A,D,and E in each age group were analyzed.Results There were 2151 children for health examination and the average serum vitamin A level was(0.32±0.08)mg/L,where the vitamin A level in the≤1-year-old group was the lowest at(0.29±0.075)mg/L.The vitamin A detection rate was 37.09%in all children,and was the highest at 54.19%in the≤1-year-old group.The average serum 25(OH)D level was(34.24±9.31)μg/L,and was the lowest at(25.58±8.67)μg/L in the>6-year-old group.The detection rate of moderate and low level 25(OH)D was 33.56%(722/2151)in all subjects,and was the highest at 77.89%in the>6-year-old group.The average serum vitamin E level was(10.69±3.57)mg/L in all children,and was the lowest at(8.59±1.96)mg/L in the>6-year-old group.The detection rate of moderate and low level vitamin E was 5.57%(120/2151)among all subjects,and was the highest at 20%in the>6-year-old group.The levels of serum 25(OH)D and vitamin E in boys were lower than those in girls.The level of serum 25(OH)D in 6-year-<age≤14-year-old boy group was lower than that of girl group(P=0.043).The level of serum vitamin E in the≤1-year-old boy group and the 1-year-old<age≤3-year-old boy group was lower than that of girl groups.Conclusions The vitamin A level in the≤1-year-old group is the lowest.The levels of 25(OH)D and vitamin E in children gradually decrease as the increase of age.
作者
孙蕾
盛晓静
殷勤
SUN Lei;SHENG Xiaojing;YIN Qin(Department of Child Healthcare,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China)
出处
《徐州医科大学学报》
CAS
2022年第3期207-211,共5页
Journal of Xuzhou Medical University
