摘要
目的探讨胸腺五肽联合抗结核方案对老年肺结核患者症状改善及免疫功能的影响。方法选择2018年10月-2021年5月盱眙县人民医院收治的65例老年肺结核患者,按照入院顺序尾数的单双数分为常规组(n=32)和联合组(n=33)。常规组应用抗结核方案治疗,联合组在常规组基础上联合胸腺五肽治疗,比较两组免疫功能[T淋巴细胞亚群-3^(+)(CD3^(+))、CD4^(+)、CD4^(+)/CD8^(+)、免疫球蛋白-G(IgG)]、症状改善情况(痰菌转阴率、病灶吸收率及空洞闭合率)、血清炎性因子[白细胞介素-6(IL-6)、转化生长因子-β(TGF-β)、单核细胞趋化蛋白-1(MCP-1)]及不良反应发生率。结果治疗后,联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IgG水平高于常规组,差异有统计学意义(P<0.05);联合组痰菌转阴率、病灶吸收率及空洞闭合率高于常规组,但差异无统计学意义(P>0.05);联合组IL-6、TGF-β、MCP-1低于常规组,差异有统计学意义(P<0.05);联合组不良反应发生率与常规组比较,差异无统计学意义(P>0.05)。结论胸腺五肽联合抗结核方案治疗老年肺结核的效果确切,可促进患者症状改善,降低血清炎性因子水平,且对机体免疫功能影响小,用药安全性高。
Objective To investigate the effect of thymopentin combined with anti-tuberculosis regimen on symptom improvement and immune function in elderly patients with pulmonary tuberculosis.Methods A total of 65 elderly patients with pulmonary tuberculosis admitted to Xuyi County People’s Hospital from October 2018 to May 2021 were selected and divided into routine group(n=32)and combined group(n=33)according to the single and double number of admission order tails.The conventional group was treated with antituberculosis regimen,and the combined group was treated with thymopentin on the basis of the conventional group.The immune function[T lymphocyte subsets-3^(+)(CD3^(+)),CD4^(+),CD4^(+)/CD8^(+),immunoglobulin-G(IgG)],symptom improvement(sputum negative conversion rate,lesion absorption rate and cavity closure rate),serum inflammatory factors[interleukin-6(IL-6),transforming growth factor-β(TGF-β),monocyte chemoattractant protein-1(MCP-1)]and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and IgG in the combined group were higher than those in the conventional group,and the difference was statistically significant(P<0.05).The sputum negative conversion rate,lesion absorption rate and cavity closure rate in the combined group were higher than those in the conventional group,but the difference was not statistically significant(P>0.05).The levels of IL-6,TGF-β and MCP-1 in the combined group were lower than those in the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and the conventional group(P>0.05).Conclusion Thymopentin combined with anti-tuberculosis regimen is effective in the treatment of elderly pulmonary tuberculosis,which can promote the improvement of patients’symptoms,reduce the level of serum inflammatory factors,have little effect on the immune function of the body,and have high medicati
作者
羊海峰
YANG Hai-feng(Department of Infection,Xuyi County People's Hospital,Xuyi 211700,Jiangsu,China)
出处
《医学信息》
2022年第7期168-170,共3页
Journal of Medical Information
关键词
肺结核
抗结核方案
胸腺五肽
免疫功能
炎性因子
Pulmonary tuberculosis
Antituberculosis regimen
Thymopentin
Immune function
Inflammatory factors
