摘要
2型糖尿病已成为全球增长最快的公共卫生问题之一,发病率逐年增高。遗传因素、生活方式以及高脂肪和高能量的饮食习惯是导致2型糖尿病的3个主要高风险因素。人体肠道内栖息着大量的细菌、正常病毒群、真菌群、螺旋体群等,它们构成了一个复杂而动态的肠道微生态系统。近年来,大量研究表明肠道菌群紊乱是2型糖尿病胰岛素抵抗快速进展的又一大诱因。本文从2型糖尿病患者肠道菌群特点、肠道菌群对2型糖尿病的影响及作用机制、基于肠道菌群防治2型糖尿病的方法3个方面就肠道菌群对2型糖尿病的影响进行综述,以期为2型糖尿病的预防和治疗提供理论依据。
Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide and the incidence is increasing year by year.Genetic constituents,lifestyle,and high-fat and high-energy dietary habits are three major factors that contribute to high risk of type 2 diabetes mellitus.The human intestine is home to a large number of bacteria,normal viruses,fungi,spirochetes,etc,which constitute a complex and dynamic ecosystem.In recent years,a large number of studies have shown that intestinal flora disorder is another major cause of the rapid progress of insulin resistance in type 2 diabetes mellitus.This paper reviews the characteristics of intestinal flora in patients with type 2 diabetes mellitus,the effect and mechanism of intestinal flora on type 2 diabetes mellitus,and the methods of prevention and treatment of type 2 diabetes mellitus based on intestinal flora,in order to provide theoretical basis for the prevention and treatment of type 2 diabetes mellitus.
作者
刘佳妮
张静寅
储倩雯
LIU Jia-ni;ZHANG Jing-yin;CHU Qian-wen(School of Pharmacy,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Department of Pharmacy,Jiading District Central Hospital Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai 201800,China)
出处
《医学信息》
2022年第7期22-25,共4页
Journal of Medical Information
基金
上海市临床药学重点专科建设项目(编号:YXZDZK-01)
上海健康医学院附属嘉定区中心医院中青年骨干培养项目(编号:ZQN202005)
上海市嘉定区卫生健康委员会中医药科研项目基金(编号:2020-KY-ZYY-07)。
关键词
肠道菌群
2型糖尿病
代谢产物
Intestinal flora
Type 2 diabetes mellitus
Metabolites
