摘要
目的 观察麻杏石甘汤加味联合诱导排痰辅助治疗小儿支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)风热闭肺证的临床疗效。方法 选取2020年1—10月安徽中医药大学附属芜湖市中医医院儿科收治的MPP风热闭肺证患儿80例,按照随机数字表法分为对照组和治疗组,各40例。对照组给予阿奇霉素注射液静脉滴注,每日1次;根据具体病症给予退热、化痰、止咳及补液等综合治疗;硫酸特布他林雾化吸入用溶液及吸入用乙酰半胱氨酸溶液雾化吸入,每日2次。治疗组在对照组治疗方法的基础上予高渗盐水雾化及机械振动拍背联合麻杏石甘汤加味口服。2组均以7 d为1个疗程,治疗1个疗程后统计临床疗效。结果 对照组总有效率为75.0%(30/40),治疗组为92.5%(37/40),2组比较,差异有统计学意义(P<0.05)。治疗前2组发热、咳嗽气喘、咳痰、舌脉证候评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述中医证候评分均明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组WBC计数及C-反应蛋白(CRP)、白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标水平均明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。2组均未出现头晕、头痛、恶心、呕吐、腹痛、腹泻、皮疹等不良反应。结论 麻杏石甘汤加味口服联合诱导排痰辅助治疗小儿MPP风热闭肺证疗效显著,不仅能有效调节炎性指标,改善中医证候,而且无不良反应,值得临床推广应用。
Objective To observe the clinical efficacy of modified Maxing Shigan Tang(麻杏石甘汤)combined with induced expectoration in adjuvant treatment of mycoplasma pneumoniae pneumonia(MPP)in children with wind-heat obstructing lung syndrome.Methods From January to October of 2020,80 cases of MPP in children with wind-heat obstructing lung syndrome admitted into pediatrics department of Wuhu Hospital of TCM were chosen and divided into control group and treatment group according to the random number table method,with 40 cases in each group.The control group was given intravenous drip of azithromycin injection,once per day.According to the specific disease,comprehensive treatment was given,namely abatement of fever,resolving phlegm,relieving cough and fluid infusion;Nebulization inhalation of terbutaline sulfate solution for nebulization and acetylcysteine solution for inhalation was given,twice a day.On the basis of the therapeutic method of the control group,the treatment group was given hypertonic saline nebulization,mechanical vibration backslap combined with modified Maxing Shigan Tang.Both groups took 7 days as 1 course of treatment,and we kept statistics about the clinical efficacy after 1 course of treatment.Results The total effective rate was 75.0%(30/40)in the control group and 92.5%(37/40)in the treatment group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in clinical manifestations scores of fever,cough and dyspnea,expectoration,tongue and pulse(P>0.05),indicating comparability.After treatment,the above-mentioned TCM clinical manifestations scores of the 2 groups all significantly decreased,and the differences were statistically significant than those in the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).Before treatment,the difference was not statistically significant in WBC count,levels of C-reactive protein(CRP),interleukin-1β(IL-1β)and interleukin
作者
汪思梦
陈妍
金鑫
毛庆东
WANG Simeng;CHEN Yan;JIN Xin;MAO Qingdong(Professional Master Training Base,Wuhu Hospital of TCM Affiliated to Anhui University of Chinese Medicine,Wuhu,Anhui,241002,China;Department of Pediatrics,Wuhu Hospital of TCM,Wuhu,Anhui,241002,China)
出处
《中医儿科杂志》
2022年第2期44-48,共5页
Journal of Pediatrics of Traditional Chinese Medicine
基金
2020年度安徽省中医药高等医学专科学校校级自然科学研究重点项目(ZRKXZ202006)。
关键词
支原体肺炎
小儿
风热闭肺证
麻杏石甘汤
诱导排痰
临床观察
mycoplasma pneumoniae pneumonia(MPP)
children
wind-heat obstructing lung syndrome
Maxing Shigan Tang(麻杏石甘汤)
induced expectoration
clinical observation
