摘要
目的探讨中西医结合治疗对难治性支原体肺炎(RMPP)患儿血清中炎性因子、免疫功能及临床效果的影响。方法选取2018年1月—2019年3月收治的RMPP患儿80例,按照随机数字表法分为对照组和观察组,每组40例。对照组给予注射用乳糖酸红霉素、盐酸溴己新片、阿奇霉素干混悬剂口服治疗,同时给予吸入用布地奈德混悬液联合吸入用复方异丙托溴铵溶液雾化治疗。观察组在对照组的治疗基础上给予黄连解毒汤联合麻杏石甘汤。观察两组患者的临床治疗效果,临床症状(发热、咳嗽及肺部啰音)消退时间,血清中免疫因子[CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)],炎症因子[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]水平及不良反应情况。结果观察组治疗后临床总有效率为95.0%(38/40),明显高于对照组的80.0%(32/40),差异具有统计学意义(P<0.05)。观察组患者治疗后与对照组比较,发热、咳嗽及肺部啰音消失时间均明显缩短(P<0.05)。与对照组治疗后比较,观察组患者CD3^+、CD4^+/CD8^+明显升高,CD8^+、IgA、IgM、IgG、IL-6、IL-10及TNF-α明显降低,差异具有统计学意义(P<0.05)。观察组不良反应发生率显著低于对照组,差异具有统计学意义(P<0.05)。结论中西医结合治疗RMPP患儿能有效提高其临床效果,改善临床症状,降低炎症反应,提高机体免疫功能,降低不良反应发生率,值得临床推广应用。
Objective To explore the effect of integrated traditional Chinese and Western medicine on serum inflammatory factors,immune function and clinical effects in children with refractory mycoplasmal pneumonia(RMPP).Methods From January 2018 to March 2019,80 children with refractory mycoplasma pneumoniae were randomly divided into control group(n=40)and observation group(n=40).The control group was treated with erythromycin,and the observation group was given Huanglian Jiedu Decoction combined with Maxing Shigan Decoction on the basis of the treatment of the control group.clinical symptoms(fever,cough and lung rales)resolution time,serum immune factors[CD3^+,CD4^+,CD8^+,CD4^+/CD8^+,immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)]Level and adverse reactionswere observed.Results The total effective rate of the observation group(95.0%)was significantly higher than that of the control group(80.0%),the difference was statistically significant(P<0.05).Compared with the control group after treatment,the time of treatment for fever,the time of cough regression and the time of disappearance of lung sputum were significantly shortened in the observation group(P<0.05),the serum levels of CD3^+were increased,CD8^+levels were decreased,CD4^+/CD8^+ratio was significantly increased,IgA,IgM,IgG levels were significantly decreased,IL-6,IL-10 and The TNF-αcontent was significantly reduced,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control(P<0.05).ConclusionIntegrative Chinese and Western medicine treatment of children with refractory mycoplasma pneumonia can effectively improve its clinical effects,improve clinical symptoms,reduce inflammatory response,improve immune function,reduce the incidence of adverse reactions,and is worthy of clinical promotion.
作者
贺卫超
张旭杰
张伟杰
张有起
HE Wei-chao;ZHANG Xu-jie;ZHANG Wei-jie;ZHANG You-qi(Department of Pediatrics,Chuzhou Central Hospital,Cangzhou Hebei 061001;National Medical Center,Chuzhou Central Hospital,Cangzhou Hebei 061001;Department of Traditional Chinese Medicine,Armed Police General Hospital,Beijing 100039)
出处
《世界中西医结合杂志》
2020年第6期1148-1151,1159,共5页
World Journal of Integrated Traditional and Western Medicine
基金
沧州市重点研发计划指导项目(172302126)。
关键词
难治性支原体肺炎
血清炎性因子
免疫功能
中西医结合疗法
Integrative Chinese and Western Medicine
Maxing Shigan Decoction
Refractory Mycoplasma Pneumoniae Pneumonia
Clinical Effect
