摘要
目的探讨生殖道沙眼衣原体(CT)和生殖支原体(Mg)与女性不孕不育的相关性。方法选取2016年1月至2018年3月佛山市南海区人民医院收治的165例不育不孕患者作为病例组,选取同期100例正常生育女性为对照组。采用RT-PCR技术检测Mg及CT,酶联免疫法检测血清中抗子宫内膜抗体(EmAb),比较两组患者Mg及CT的阳性检出率、病例组中Mg或CT阳性患者与阴性患者的EmAb阳性率、生殖道CT及Mg感染与女性不孕不育的相关性。结果病例组患者Mg和CT阳性检出率均高于对照组,差异有统计学意义(P<0.05)。病例组患者中,Mg和CT阳性患者的EmAb阳性率高于Mg和CT阴性患者,差异有统计学意义(P<0.05)。Spearman相关性分析显示生殖道CT及Mg感染与女性不孕不育成正相关(P<0.05)。结论CT和Mg与女性不孕不育有相关性,CT和Mg以及EmAb可作为辅助诊断女性不孕不育的重要有效手段。
Objective To explore the relationship between Chlamydia trachomatis(CT),Mycoplasma genitalium(Mg)and female infertility.Methods From January 2016 to March 2018,165 female infertility patients who visited Nanhai District People′s Hospital of Foshan were selected as the case group,and 100 healthy women were set as control group at the same time.RT-PCR was used to detect Mg and CT,and enzyme-linked immunosorbent assay was used to detect anti-endometrial antibody(EmAb)in serum.The positive rate of Mg and CT in the two groups,the positive rate of EmAb in Mg or CT positive and negative patients in the case group,and the correlation between genital CT and Mg infection and female infertility were compared.Results The positive rates of Mg and CT in case group were higher than those in control group,the differences were statistically significant(P<0.05).In the case group,the positive rate of EmAb in Mg and CT positive patients was higher than that in Mg and CT negative patients,the difference was statistically significant(P<0.05).Spearman correlation analysis showed that reproductive tract CT and Mg infection were positively correlated with infertility(P<0.05).Conclusions CT and MG are significantly correlated with female infertility.CT and MG and EmAb can be used as an important and effective method to diagnose female infertility.
作者
袁晓文
袁诗韵
梁景星
吴国新
吴智鑫
张欣
关紫云
YUAN Xiaowen;YUAN Shiyun;LIANG Jingxing;WU Guoxin;WU Zhixin;ZHANG Xin;GUAN Ziyun(Department of Laboratory Medicine,Nanhai District People′s Hospital of Foshan,Guangdong Province,Foshan528200,China;Department of Emergency Medicine,Nanhai District People′s Hospital of Foshan,Guangdong Province,Foshan528200,China;Department of Medical Records Statistics Room,Nanhai Hospital of Guangdong Provincial People′s Hospital,Guangdong Province,Foshan528251;Department of Emergency Medicine,Foshan Hospital of Traditional Chinese Medicine,Guangdong Province,Foshan528200,China;Department of Gynaecology,Nanhai District People′s Hospital of Foshan,Guangdong Province,Foshan528200,China)
出处
《中国当代医药》
CAS
2022年第9期111-114,共4页
China Modern Medicine
基金
广东省佛山市卫生和计生局医学科研课题(20190286)
广东省佛山市科技局科技创新项目(2017AG100061、2017AG100082)。
关键词
沙眼衣原体
生殖支原体
抗子宫内膜抗体
女性不孕不育
Chlamydia trachomatis
Mycoplasma genitalium
Anti endometrial antibodies
Female infertility
