摘要
急性呼吸窘迫综合征(ARDS)的发病机制复杂,炎症反应在ARDS的病理进程中具有关键作用。高迁移率族蛋白B1(HMGB1)和Toll样受体4(TLR4)是促发炎性反应的关键介质,许多证据表明HMGB1和TLR4在ARDS中发挥重要作用,可能成为ARDS的治疗靶点。就HMGB1、TLR4和HMGB1/TLR4信号通路在ARDS炎症发展中的作用及相关治疗进展进行综述。
The pathogenesis of acute respiratory distress syndrome(ARDS)is complex,inflammation plays an important role in the pathological process of ARDS.Many studies have shown that high mobility group box 1 protein(HMGB1)and toll-like receptor 4(TLR4),as inflammatory mediators,are important components in ARDS,which may become the therapeutic target of ARDS.This article reviews the role of HMGB1,TLR4 and HMGB1/TLR4 signaling pathway in the development of inflammation and the related treatment progression of ARDS.
作者
舒小燚
李有霞
范绍辉
王红嫚
SHU Xiaoyi;LI Youxia;FAN Shaohui;WANG Hongman(Department of Respiratory and Critical Care Medicine,the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Zhuhai 519100,China)
出处
《天津医药》
CAS
北大核心
2022年第4期433-438,共6页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81960023)
贵州省卫生健康委科学技术基金项目(gzwkj2021-093)。
