摘要
肾纤维化是大多数慢性肾脏疾病进展至终末期肾病的基本病理改变,其发病过程受到多种信号通路的调节。肾纤维化过程以持续炎症为特征,包括炎性细胞浸润和细胞因子分泌。Toll样受体4(Toll-likereceptor-4,TLR4)信号分子是介导肾脏炎症及纤维化的重要桥梁,可通过核因子-κB(nuclear factor-kappa B,NF-κB)激活炎性因子大量释放而造成肾纤维化。TLR4在肾纤维化中发挥重要作用。
Renal fibrosis is the basic pathological change of most chronic kidney diseases progression to end-stage renal disease.The pathogenesis is regulated by various signaling pathways.The renal fibrosis process is characterized by persistent inflammation,including inflammatory cell infiltration and cytokine secretion.Toll-like receptor 4(TLR4) signaling molecule is an important bridge mediating renal inflammation and fibrosis,which can cause renal fibrosis by activating the release of inflammatory factors by nuclear factor-kappa B(NF-κB).TLR4 plays an important role in renal fibrosis.
作者
宋学萍
梁娟
王颖娥
黄强
刘东
SONG Xueping;LIANG Juan;WANG Ying’e;HUANG Qiang;LIU Dong(Department of Nephrology,The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Lanzhou 730050,China)
出处
《临床与病理杂志》
2020年第1期140-144,共5页
Journal of Clinical and Pathological Research
基金
甘肃青年科学基金项目(81600700)~~
