摘要
卵巢早衰(POF)是一种高度异质性疾病,育龄期女性中其发生率约为3.7%。POF发病机制尚未完全阐明,但目前研究结果认为自身免疫紊乱在POF发生发展中起到重要作用,包括免疫细胞异常、抗卵巢抗体的高检出率、与自身免疫性疾病的高度关联,发现并治疗这些免疫紊乱为POF的预防和治疗提供了新方向,本文就POF与自身免疫紊乱的研究进展进行综述。
Premature ovarian failure(POF)is a highly heterogeneous disease,with an incidence of about 3.7%in women of reproductive age.The pathogenesis of POF has not been fully elucidated,but the current research results suggest that autoimmune disorders play an important role in the occurrence and development of POF,including abnormal immune cells,resistance of ovarian antibodies with a high detection rate,highly associated with the autoimmune diseases,finding and treating these immune disorders provides a new direction for the prevention and treatment of POF.This article reviews the research progress of POF and autoimmune disorders.
作者
方雨晴
李艳辉
Fang Yuqing;Li Yanhui(Department of Obstetrics and Gynecology,Union Hospital Affiliated to Tongji Medical College,Huazhong University of science and technology,Wuhan 430022,China)
出处
《实用妇科内分泌电子杂志》
2022年第3期61-63,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
卵巢早衰
免疫细胞
抗卵巢抗体
自身免疫性疾病
Premature ovarian failure
Immune cells
Anti-ovarian antibody
Autoimmune diseases
