摘要
肠胶质细胞(enteric glial cells,EGCs)是肠神经系统的重要组成部分,是聚居在肠壁中维持肠道稳态的细胞群。文章阐述了EGCs、肠道屏障功能以及二者的相互关系。EGCs在肠道全层都有广泛分布,但主要聚居在肌间和黏膜下的神经丛中。EGCs通过包裹神经元的胞体、轴突以及微血管从黏膜下层延伸至肠黏膜层。黏膜下神经丛中的EGCs距离肠道上皮细胞最近,对肠道屏障的影响也最为显著。EGCs对肠道屏障功能的调节是通过分泌活性因子抑制肠道炎症及上调紧密连接蛋白的表达而实现。多种因素会对EGCs的活性产生影响。优化对EGCs活性的调控成为保护患者肠道屏障功能的重要手段。
Enteric glial cells(EGCs),an important component of the enteric nervous system,are a group of cells that inhabit in the intestinal wall to maintain intestinal homeostasis.This article describes EGCs,intestinal barrier function and their interrelation⁃ships.EGCs are widely distributed in the all intestinal tract,but mainly concentrated in the intermuscular and submucosal nerve plex⁃us.In the submucosal nerve plexus,EGCs extends from the submucosa to the intestinal mucosal layer by surrounding neuronal bodies and axons as well as blood microvessels.Because the EGCs in the submucosal nerve plexus are the closest to the intestinal epithelial cells,they also have the most significant effect on the intestinal barrier.EGCs regulate intestinal barrier function by secreting factors that inhibit intestinal inflammatory and up⁃regulate expression of tight junction protein.Multiple factors can affect the activity of EGCs.Optimizing the regulation of EGCs activity becomes an important means to protect the intestinal barrier of patients.
作者
赵友会
蒙俊
杨堃
Zhao Youhui;Meng Jun;Yang Kun(Department of Anesthesiology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Cardiovascular Surgery,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《国际麻醉学与复苏杂志》
CAS
2022年第3期318-321,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81760348)
云南省高层次卫生计生技术人才培养(D⁃2018019)。
关键词
肠
神经系统
胶质细胞
肠道屏障
Intestine
Nervous system
Glial cell
Intestinal barrier
