摘要
肠稳态是由包括肠上皮细胞在内的多种肠道成分、肠道内环境以及大量神经内分泌调控通路相互作用所构成的动态平衡状态.近年来研究显示,作为肠道神经系统(enteric nervous system,ENS)的核心,肠胶质细胞(enteric glial cell,EGC)可能通过参与调控肠道运动、营养吸收与分泌、肠道免疫、肠道防御等多种肠道功能在肠稳态调节机制中发挥关键作用.同时,异常活化的EGC也可能是炎症性肠病、肠道感染、肠道功能紊乱等肠道疾病以及代谢性疾病、帕金森病等肠外疾病的重要致病因素.本文就近年来EGC相关研究进展结合本课题组的研究工作进行简要综述,以期推动国内在这一领域研究的进一步发展.
The intestine contains multiple components including epithelial cells,microbiome as well as various neuroendocrine pathways,all of which are essential for maintaining dynamic mucosal homeostasis through complex interactions among different components in the gastrointestinal tract.Beyond the basic neurosupportive and neurotrophic effects,growing evidence reveals the key role of enteric glial cells（EGCs） in the modulation of bowel movement,nutrient absorption and secretion,intestinal immunity as well as barrier function.As well,abnormally activated EGCs are believed to be a vital player in the pathogenesis of a variety of diseases including inflammatory bowel disease,intestinal barrier dysfunction and infections.Here we provide a brief overview of recent research progress about the precise role and the molecule mechanisms of EGCs in modulating intestinal homeostasis,and highlight the critical role of EGC in various intestinal diseases.
出处
《世界华人消化杂志》
CAS
2016年第25期3657-3665,共9页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81470803
81270451
81330013
教育部创新团队发展计划基金资助项目
No.教技函[2013]59号
重庆市应用开发合作基金资助项目
No.CSTC2014YYKFA110016~~
关键词
肠胶质细胞
肠稳态
肠黏膜屏障
肠神经系统
Enteric glial cell
Intestinal homeostasis
Intestinal epithelial barrier
Enteric nerve system
