摘要
目的探讨舒血宁注射液联合乙哌立松治疗椎动脉型颈椎病的临床效果。方法选取2019年4月—2020年11月河南科技大学第一附属医院开元院区收治的166例椎动脉型颈椎病患者,以随机数字表法分成对照组(83例)和治疗组(83例)。对照组口服盐酸乙哌立松片,1片/次,3次/d。在对照组基础上,治疗组静脉滴注舒血宁注射液,20 mL加入5%葡萄糖注射液250 mL,1次/d。两组连续治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者眩晕残障程度评定量表(DHI)、颈椎功能障碍指数(NDI)和椎动脉型颈椎病功能评定量表(FS-CSA)评分,基底动脉(BA)、左椎动脉(LVA)和右椎动脉(RVA)的平均血流速度,血清肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、一氧化氮(NO)水平。结果治疗后,治疗组总有效率为96.4%,较对照组的84.3%显著升高(P<0.05)。治疗后,两组患者DHI、NDI和FS-CSA评分均显著下降(P<0.05),且治疗组降低更显著(P<0.05)。治疗后,两组BA、LVA和RVA的平均血流速度均显著增加(P<0.05),且治疗组增加更显著(P<0.05)。治疗后,两组血清TNF-α、ET-1水平显著下降,而血清NO水平则显著上升(P<0.05),且治疗组血清TNF-α、ET-1和NO水平明显好于对照组(P<0.05)。结论舒血宁注射液联合乙哌立松治疗椎动脉型颈椎病疗效确切,可安全有效地减轻患者眩晕等症状,改善椎动脉血流动力学,纠正血管内皮功能紊乱,提高患者生活质量。
Objective To investigate the clinical effect of Shuxuening Injection combined with eperisone in treatment of cervical spondylosis of vertebral artery type. Methods Patients(166 cases) with cervical spondylosis of vertebral artery type in Kaiyuan Branch, First Affiliated Hospital of Henan University of Science and Technology from April 2019 to November 2020 were divided into control(83 cases) and treatment(83 cases) group by random number table method. Patients in the control group were po administered with Eperisone Hydrochloride Tablets, 1 tablet/time, three times daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 20 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, the scores of DHI, NDI and FS-CSA, the vertebral artery hemodynamic parameters, the levels of serum TNF-α, ET-1 and NO in two groups before and after treatment were compared.Results After treatment, the total effective rate of the treatment group was 96.4%, which was significantly higher than that of the control group(84.3%)(P < 0.05). After treatment, the scores of DHI, NDI and FS-CSA in two groups were significantly decreased(P < 0.05), especially in the treatment group(P < 0.05). After treatment, the mean blood flow velocity of BA, LVA and RVA in two groups were significantly increased(P < 0.05), especially in the treatment group(P < 0.05). After treatment, the levels of serum TNF-α and ET-1 were significantly decreased, while the level of serum NO were significantly increased in two groups,(P < 0.05) and the levels of TNF-α, ET-1, and NO in the treatment group were significantly better than those in the control group(P < 0.05). Conclusion Shuxuening Injection combined with eperisone is effective in treatment of cervical spondylosis of vertebral artery type, which can safely and effectively reduce symptoms such as vertigo, improve vertebral artery hemodynamics and correc
作者
宋媛媛
陈靖军
赵永凯
勾志静
赵向波
张沛
SONG Yuan-yuan;CHEN Jing-jun;ZHAO Yong-kai;GOU Zhi-jing;ZHAO Xiang-bo;ZHANG Pei(Department of Pain,Kaiyuan Branch,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Pain,Jinghua Branch,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)
出处
《现代药物与临床》
CAS
2022年第1期151-155,共5页
Drugs & Clinic
