摘要
目的探究超脉冲CO_(2)点阵激光治疗烧伤后面部色素沉着的效果。方法自2018年6月至2020年6月,宝鸡市中心医院对80例烧伤后面部色素沉着的患者,采用随机数字表法进行分组,每组40例。对照组采用强脉冲光治疗,观察组采用超脉冲CO_(2)点阵激光治疗,两组治疗后均涂抹重组牛碱性成纤维细胞生长因子凝胶,2 d后七子白中药面膜外敷。所有患者分别于治疗前、治疗后1、2、3个月测定和比较两组面部图像评分(色素沉着、紫质)、皮肤性质评分(水分、弹性)、氧化应激指标(丙二醛、超氧化物歧化酶、过氧化脂质)变化情况,对比总有效率的差异。结果总有效率:观察组为95.00%(38/40),对照组为85.00%(34/40),两组差异有统计学意义(P<0.05)。所有患者均无不良反应发生。两组患者面部图像评分,皮肤性质评分,氧化应激指标治疗后1、2、3个月较治疗前明显改善,且观察组各时间段指标数值优于对照组,差异有统计学意义(P<0.05)。结论超脉冲CO_(2)点阵激光治疗烧伤后面部色素沉着效果确切,可以有效地抑制局部组织氧化应激反应,值得临床推广使用。
Objective To study the efficacy of ultra-pulse CO_(2) fractional laser in the treatment of facial pigmentation after burns.Methods From June 2018 to 2020, 80 patients with facial pigmentation after burns were randomly divided into 2 groups, 40 cases in each group. The control group was treated by intense pulsed light and the observation group was treated by ultra-pulsed CO_(2) fractional laser. The recombinant bovine basic fibroblast growth factor gel was performed in both groups after treatment and changed to traditional Chinese medicine mask of "Qibai San" at 2 days after treatment. The changes of facial image scores(pigmentation and purpurin), skin property scores(moisture and elasticity) and oxidative stress indicators(malondialdehyde, superoxide dismutase and lipid peroxidase) before treatment and at 1 month, 2 months and 3 months after treatment were detected and compared. The difference in total effective rate was compared. Results The total effective rate was 95.00%(38/40) in the observation group and 85.00%(34/40) in the control group, the difference was statistically significant(P<0.05). No adverse reactions were found in all patients. The scores of facial image, skin property and oxidative stress indicators ofboth groups at 1 month, 2 months and 3 months after treatment were significantly improved. The index values in observation group were better than those in control group at each period, the difference was statistically significant(P<0.05). Conclusion Ultra-pulse CO_(2) fractional laser has a definite efficacy in the treatment of facial pigmentation after burns. This method can effectively inhibit the oxidative stress response of local tissues. It should be considerable for clinical popularization.
作者
马伟欢
习耀峰
赵婵
张成锋
张晔
张秋霞
陈荣
MA Weihuan;XI Yaofeng;ZHAO Chan;ZHANG Chengfeng;ZHANG Ye;ZHANG Qiuxia;CHEN Rong(Department of Plastic Surgery and Burns,Baoji Central Hospital,Baoji 721008,China)
出处
《中国美容整形外科杂志》
CAS
2022年第2期83-86,共4页
Chinese Journal of Aesthetic and Plastic Surgery
