摘要
目的运用Meta分析,综合评价调Q激光联合强脉冲光治疗黄褐斑的临床疗效。方法计算机检索Pubmed、中国知网、万方、维普、Cochrane、Web of science、Elsevier science等数据库,收集调Q激光联合强脉冲光与调Q激光治疗黄褐斑的随机对照试验(Randomized controlled trial,RCT),检索时限至2019年12月。由5位研究者独立进行文献筛选、资料提取,利用RevMan 5.3对结局指标进行Meta分析,并进行发表偏倚检验。结果最终纳入7项RCTs,共548例患者,Meta分析显示:调Q激光联合强脉冲光治疗黄褐斑的总有效率优于调Q激光(RR=1.25,95%CI[1.10,1.41],Z=3,58,P=0.0003)。不良反应和复发率无循证结论。结论调Q激光联合强脉冲光是治疗黄褐斑的有效手段,没有证据表明不良反应和复发率低于单一治疗。
Objective To evaluate the clinical efficacy of Q-switched laser combined with intense pulsed light(IPL)on the treatment of melasma by Meta-analysis.Methods Computer retrieval of Pubmed,CNKI,WanFang,VIP,Web of science,Elsevier science and Cochrane database.Randomized controlled trial(RCT)of Q-switched laser combined with IPL in the treatment of melasma was collected,the retrieval time was up to December 2019.Five researchers independently screened the literature and extracted the data.RevMan 5.3 was used to make a meta-analysis of the outcome indicators and test the publication bias.Results Seven RCTs were included in the our study,a total of 548 patients were enrolled.Meta-analysis shows that the total effective rates of Q-switched laser combined with IPL on the treatment of melasma is significantly higher than Q-switched laser(RR=1.25,95%CI[1.10,1.41],Z=3.58,P=0.0003).There is no evidence-based conclusion on adverse reactions and recurrence rate because of the limitations of the data.Conclusions The result shows that Q-switched laser combined with IPL is an effective method on the treatment of melasma,no evidence shows that adverse reactions and recurrence rates are lower than those of Q-switched laser.
作者
蒋帅
李华玲
徐剑丹
陶佳
陈菊萍
JIANG Shuai;LI Hua-ling;XU Jian-dan;TAO Jia;CHEN Ju-ping(Nanjing Xuanwu jianziji medical cosmetology clinic,Nanjing 210000,China;Medical School of Yangzhou University,Yangzhou 225000,China;Department of Dermatology affiliated Hospital of Yangzhou University,Yangzhou 225009,China)
出处
《中国医疗美容》
2021年第1期104-108,共5页
China Medical Cosmetology
关键词
黄褐斑
调Q激光
联合
强脉冲光
META分析
Melasma
Q-switched Laser
Combine
Intense pulsed light
Meta-analysis
