摘要
目的探讨单核细胞趋化蛋白-1、巨噬细胞炎性蛋白1α和正常T细胞表达分泌调节活化因子在美国国立卫生研究院Ⅲ型前列腺炎患者前列腺液中的表达及其临床价值。方法将40例正常T细胞表达分泌调节活化因子Ⅲ型前列腺炎患者设为研究组,按照前列腺液中是否有白细胞分为美国国立卫生研究院ⅢA型组与美国国立卫生研究院ⅢB型组,各20例,选取20名健康志愿者设为对照组。3组均取前列腺液标本,检测单核细胞趋化蛋白-1、巨噬细胞炎性蛋白1α、正常T细胞表达分泌调节活化因子水平,通过受试者工作特征曲线评价检测指标的诊断效能。结果美国国立卫生研究院ⅢA型前列腺炎患者前列腺液单核细胞趋化蛋白-1、巨噬细胞炎性蛋白1α、正常T细胞表达分泌调节活化因子水平显著高于对照组(P<0.05或0.01),美国国立卫生研究院ⅢA型组单核细胞趋化蛋白-1及正常T细胞表达分泌调节活化因子水平显著高于美国国立卫生研究院ⅢB型组(P<0.01),美国国立卫生研究院ⅢB型组巨噬细胞炎性蛋白1α水平显著高于对照组(P<0.05)。美国国立卫生研究院Ⅲ型前列腺炎患者前列腺液单核细胞趋化蛋白-1水平与正常T细胞表达分泌调节活化因子水平呈显著正相关(P<0.05)。受试者操作特征曲线显示,单核细胞趋化蛋白-1及正常T细胞表达分泌调节活化因子在美国国立卫生研究院ⅢA型前列腺炎的诊断中具有很高的价值,并且对美国国立卫生研究院ⅢA型前列腺炎的诊断价值高于美国国立卫生研究院ⅢB型前列腺炎,而巨噬细胞炎性蛋白1α对美国国立卫生研究院ⅢB型前列腺炎的诊断价值高于单核细胞趋化蛋白-1及正常T细胞表达分泌调节活化因子的诊断价值。结论单核细胞趋化蛋白-1、巨噬细胞炎性蛋白1α、正常T细胞表达分泌调节活化因子在美国国立卫生研究院Ⅲ型前列腺炎亚分型的鉴别中具�
Objective To investigate the expression and clinical significance of monocyte chemotactic protein-1(MCP-1),macrophage inflammatory protein-1α(MIP-1α),regulated upon activation normal T cell expressed and secreted(RANTES) in prostatic fluid of patients with National Institutes of Health-Ⅲ(NIH-Ⅲ) prostatitis.Methods Set 40 patients with RANTES-Ⅲ prostatitis as the study group.According to whether there were white blood cells in the prostatic fluid,they were divided into NIH-ⅢA group and NIH-ⅢB group,each with 20 cases,and 20 healthy volunteers were selected as the control group.Prostatic fluid samples were taken from all three groups.MCP-1,MIP-1α and RANTES levels were detected,and the diagnostic efficacy of the test indexes was evaluated by receiver operating characteristic curve(ROC).Results The levels of MCP-1,MIP-1αand RANTES in the prostatic fluid of patients with NIH-ⅢA prostatitis were significantly higher than those of the control group(P<0.05 or 0.01),and the levels of MCP-1 and RANTES in the NIH-Ⅲ A group were significantly higher than those in the NIH-Ⅲ B group(P<0.01),the level of MIP-la in the NIH-Ⅲ B group was significantly higher than that in the control group(P<0.05).The level of MCP-1 in prostatic fluid of patients with NIH-Ⅲ prostatitis was significantly positively correlated with the level of RANTES(P<0.05).ROC showed that MCP-1 and RANTES were of high value in the diagnosis of NIH-Ⅲ A prostatitis,and the diagnostic value of NIH-Ⅲ A prostatitis was higher than that of NIH-Ⅲ B prostatitis.The diagnostic value of MIP-1α for NIH-Ⅲ B prostatitis was higher than that of MCP-1 and RANTES.Conclusions MCP-1,MIP-1α and RANTES have high clinical value in the identification of NIH-Ⅲ prostatitis subtypes,and are expected to become one of the basis for the diagnosis of NIH-Ⅲ prostatitis subtypes.
作者
何岩
吴春磊
李泽宇
宋伟航
李建昌
He Yan;Wu Chunlei;Li Zeyu;Song Weihang;Li Jianchang(The First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,Henan,China)
出处
《临床心身疾病杂志》
CAS
2022年第1期14-18,共5页
Journal of Clinical Psychosomatic Diseases
基金
河南省医学科技攻关计划项目(编号2018020350)。
关键词
前列腺炎
前列腺液
标志物
诊断
分型
prostatitis
prostatic fluid
markers
diagnosis
classification
