摘要
目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)合并高血压前期(PH)患者血清胱抑素C (Cys C)与左室几何构型的相关性。方法收集2018年7月至2021年6月就诊于山西医科大学第一医院呼吸科睡眠监测室经多导睡眠监测确诊为OSAS且为PH的患者408例。所有患者均行血清Cys C浓度测定和超声心动图检查。依据左室几何构型分类将所有患者分为4组:正常构型(NG)组297例、向心性重构(CR)组49例、离心性肥厚(EH)组33例和向心性肥厚(CH)组29例。比较4组间一般临床资料、睡眠参数、血生化参数、Cys C浓度及超声心动图参数, 并分析血清Cys C与左室几何构型的相关性。结果①血清Cys C浓度从NG组、CR组、EH组到CH组依次增高, 以CH组增高最为明显(P<0.05)。此外, 各组间体质指数(BMI)、腰围、收缩压(SBP)、舒张压(DBP)、OSAS严重程度、血氧饱和度低于90%的时间占总睡眠时间的百分比(T90)、最低血氧饱和度(Lowest-SaO2)、平均血氧饱和度(Mean-SaO2)、左室舒张末期内径(LVEDD)、室间隔舒张末期厚度(IVST)、左室后壁舒张末期厚度(LVPWT)、左室质量指数(LVMI)、相对室壁厚度(RWT)、左室射血分数(LVEF)和E/A值差异有统计学意义(均P<0.05)。②多因素Logistic回归分析显示, Cys C与CR(β=0.721, OR=2.057, P=0.047)、EH(β=0.961, OR=2.614, P=0.017)和CH(β=1.180, OR=3.254, P=0.010)均独立相关。结论 OSAS合并PH患者血清Cys C与左室几何构型间存在相关性, 提示血清Cys C可能参与了左室几何构型改变过程。
Objective To investigate the correlation between serum cystatin C(Cys C)and left ventricular geometry in patients with obstructive sleep apnea syndrome(OSAS)complicated with prehypertension(PH).Methods A total of 408 patients with PH and OSAS diagnosed by polysonogram monitoring in the sleep monitoring room of Respiratory Department,the First Hospital of Shanxi Medical University from July 2018 to June 2021 were collected.Serum Cys C concentration and echocardiography were performed in all patients.According to the classification of left ventricular geometry,all patients were divided into four groups:normal configuration(NG)group(n=297),concentric remodeling(CR)group(n=49),eccentric hypertrophy(EH)group(n=33),and concentric hypertrophy(CH)group(n=29).General clinical data,sleep parameters,blood biochemical parameters,Cys C concentration and echocardiographic parameters were compared among the four groups,and the correlation between serum Cys C and left ventricular geometry was analyzed.Results①The serum Cys C concentration increased successively from NG group,CR group,EH group to CH group,and the increase in CH group was the most obvious(P<0.05).In addition,there were statistically significant differences in body mass index(BMI),waist circumference,systolic blood pressure(SBP),diastolic blood pressure(DBP),severity of OSAS,the percentage of the time that the blood oxygen saturation was less than 90%of the total sleep time(T90),lowest oxygen saturation(Lowest-SaO2),mean oxygen saturation(Mean-SaO2),left ventricular end diastolic diameter(LVEDD),inter-ventricular septal diameter(IVST),left ventricular posterior wall thickness diameter(LVPWT),left ventricular mass index(LVMI),relative wall thickness(RWT),left ventricular ejection fraction(LVEF)and E/A among all groups(all P<0.05).②Multivariate Logistic regression analysis showed that Cys C was independently correlated with CR(β=0.721,OR=2.057,P=0.047),EH(β=0.961,OR=2.614,P=0.017)and CH(β=1.180,OR=3.254,P=0.010).Conclusions There is a correlation between serum
作者
康彩虹
王健
水雯
崔桐
张振霞
魏娜
昝禹
邢雪青
Kang Caihong;Wang Jian;Shui Wen;Cui Tong;Zhang Zhenxia;Wei Na;Zan Yu;Xing Xueqing(Department of Ultrasound,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2022年第2期101-107,共7页
Chinese Journal of Ultrasonography
基金
山西省自然科学基金项目(201901D111361)。
