摘要
免疫系统和凝血系统在体内以复杂的方式协同参与抗感染过程。伴随炎症发生的血栓形成即炎症型血栓形成,在多种疾病中被发现,与疾病进程密切相关。它是血液中级联系统(如补体、凝血和纤溶)等被激活的结果,具体机制尚不清楚。在炎症型血栓形成过程中,血细胞(血小板、各种白细胞亚群等)与内皮细胞,相互作用共同促进,扮演了关键的角色。本文就血小板在炎症型血栓形成中的作用以及抗炎症型血栓治疗的进展作一综述,着重介绍其在免疫血栓形成中的作用,及其与免疫细胞和内皮细胞的相互作用。
The immune system and the coagulation system work cooperatively in vivo in a complex way to fight against infection.Inflammation-related thrombosis(thromboinflammation)has been found in many diseases and is closely related to disease process.Thromboinflammation results from the activation of blood intermediate systems(such as complement,coagulation and fibrinolysis),but its mechanism is still unclear.The actived blood cells(the platelets,various white blood cell subgroups,etc.)and the endothelial cells play a key role in the formation of immunothrombosis.This review summarized the role of the platelets in the thromboinflammation and the progress in anti-thromboinflammation treatment,focuing on the latest findings of the pathophysiology of thromboinflammation and the impact of their interaction.
作者
杨沁雨
章泽恒
YANG Qin-yu;ZHANG Ze-heng(Department of Pharmacology,Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410001;Hunan Center for Drug Evaluation and Adverse Reaction Monitoring,Changsha 410001)
出处
《中南药学》
CAS
2022年第3期649-656,共8页
Central South Pharmacy
