摘要
目的 探讨柴胡桂枝干姜汤加减辅助治疗胃食管反流病(GERD)的临床效果。方法 选取2021年3月至2023年3月山西省长治市中医医院收治的110例GERD患者,按照随机数字表法将其分为两组,每组55例。对照组以常规西药治疗,在对照组基础上,观察组增用柴胡桂枝干姜汤加减治疗。两组均以10 d为1个疗程,3个疗程后评估两组患者的临床疗效、中医证候积分、食管动力学指标、胃肠激素指标、治疗安全性。结果 观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组烧心反酸、胃脘胀闷、嗳气早饱、少食纳差积分较治疗前降低,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组食管括约肌压力、食管下括约肌压力、食管蠕动速度较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组胃动素、肠抑胃肽高于治疗前,血管活性肠肽低于治疗前,且观察组胃动素、肠抑胃肽高于对照组,血管活性肠肽低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 柴胡桂枝干姜汤加减辅助治疗GERD有良好的治疗效果,可减轻患者的主要中医证候,改善食管动力,调整胃肠激素水平,且有良好的治疗安全性。
Objective To investigate the clinical effect of Chaihu Guizhi Ganjiang Decoction in the adjuvant treatment of gastroesophageal reflux disease(GERD).Methods A total of 110 GERD patients admitted to Changzhi Hospital of Traditional Chinese Medicine of Shanxi Province from March 2021 to March 2023 were selected and they were divided into two groups according to random number table method,with 55 cases in each group.The control group was treated with conventional Western medicine.On the basis of the control group,the observation group was treated with Chaihu Guizhi Ganjiang Decoction.Both groups were treated for ten days as a course of treatment.After three courses of treatment,clinical efficacy,traditional Chinese medicine syndrome score,esophageal dynamics index,gastrointestinal hormone index,and treatment safety of patients in both groups were evaluated.Results The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of heartburn and acid reflux,gastric distension and depression,belching and early satiety,undereating and poor appetite in two groups were lower than before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the esophageal sphincter pressure,lower esophageal sphincter pressure and esophageal peristalsis velocity of the two groups were higher than before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,motilin and gastric inhibitory polypeptide in two groups were higher than before treatment,and vasoactive intestinal peptide was lower than before treatment,and motilin and gastric inhibitory polypeptide in observation group were higher than control group,and vasoactive intestinal peptide was lower than control group,the differences were statistically significant(P<0.05).Afte
作者
郭莉
杨君
栗书元
GUO Li;YANG Jun;LI Shuyuan(Department of Spleen and Stomach Diseases,Changzhi Hospital of Traditional Chinese Medicine,Shanxi Province,Changzhi046000,China;Statistics Department,Changzhi Hospital of Traditional Chinese Medicine,Shanxi Province,Changzhi046000,China;Department of Oncology,Spleen and Stomach Diseases,Changzhi Hospital of Traditional Chinese Medicine,Shanxi Province,Changzhi046000,China)
出处
《中国医药导报》
CAS
2024年第3期144-148,共5页
China Medical Herald
基金
山西省中医药管理局科研课题(2023ZYYB072)。
关键词
胃食管反流病
柴胡桂枝干姜汤
临床疗效
中医证候
食管动力学
胃肠激素
Gastroesophageal reflux disease
Chaihu Guizhi Ganjiang Decoction
Clinical efficacy
Traditional Chinese medicine syndrome
Esophageal dynamics
Gastrointestinal hormones
