摘要
重度抑郁症(major depressive disorder,MDD)是由多种因素导致的精神疾病,可引起情绪低落及认知功能受损等症状,抗抑郁治疗前后存在大脑功能和结构的不同改变。MRI有助于进一步确定MDD相关症状的神经病理生理机制。研究发现未治疗MDD患者前额叶、扣带回、楔前叶及海马等脑区的神经活动减低,默认模式网络(default mode network,DMN)、中央执行网络(central executive network,CEN)及显著性网络(salience network,SN)功能连接增强,灰质体积减小、白质结构损伤,抗抑郁药物治疗后部分脑区神经活动增加,脑网络功能连接及灰、白质结构正常化。本文综述MDD治疗前后的MRI脑功能及结构改变,为早期诊断及抗抑郁药物疗效评估提供客观影像学依据。
Major depressive disorder(MDD) is a psychiatric disorder that is caused by varieties of factors, which can result in symptoms such as upset and cognitive impairment. Different changes in brain function and structure exist before and after antidepressant treatment.MRI can further identify the neuropathophysiological mechanisms associated with the symptoms of MDD. Recent drug-naive MDD studies have shown decreased regional brain activity in prefrontal cortex, cingulate, precuneus, hippocampus and increased functional connectivity in default mode network(DMN), central executive network(CEN), salience network(SN). These studies also exhibite the reduction of gray matter volume and disruption of white matter simultaneously. Post-treatment studies display increased brain activity in partial brain regions, which also indicate the normalization in DMN, CEN, SN, gray matter volume and white matter structure. This paper reviews the effects of major depressive disorder before and after antidepressant treatment from the perspective of functional and structural MRI to provide objective reference information for early diagnosis and curative effect evaluation.
作者
李海东
王峻
牛金亮
LI Haidong;WANG Jun;NIU Jinliang(College of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Magnetic Resonance Imaging,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第3期143-146,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:82071898)
山西省卫生健康委员会专项科技项目(编号:2020-1)。
关键词
重度抑郁症
磁共振成像
脑结构
脑功能
机制
抗抑郁药物治疗
影像标志物
major depressive disorder
magnetic resonance imaging
brain structure
brain function
mechanism
antidepressant therapy
imaging marker
