摘要
目的运用基于体素的形态学分析方法探究首发未治疗抑郁症患者的脑灰质体积变化,探讨抑郁症患者有关脑区脑结构改变,为深入理解抑郁症的发病机制提供新的思路。方法前瞻性连续纳入抑郁症患者30例,正常对照24例,使用同一台PHILPS 3.0T磁共振机器对所有受试者进行MRI结构像扫描,并采用基于体素的形态学分析方法对其脑灰质体积改变进行分析。结果患者组较正常对照组相比,左侧颞中回、右侧岛叶、左侧枕上回及右侧背外侧额上回四个脑区灰质体积明显减小(P<0.05,cluster size>45,Alphasim校正),未观察到有脑灰质体积增高的脑区。结论首发未治疗抑郁症患者较正常对照灰质体积减小的脑区主要涉及额颞枕叶及岛叶,表明抑郁症的发生与多个脑区相关联。
Objective Voxel-based morphological analysis was used to explore the changes of gray matter volume in patients with first-episode untreated depression,and to explore the structural changes of brain regions in patients with depression,so as to provide new ideas for in-depth understanding of the pathogenesis of depression.Methods 30 patients with first-episode untreated depression and 22 healthy volunteers were included.Used the PHILPS 3.0T MRI scanner for sagittal three-dimensionl brain structre scans,the brain structure images of the two groups were studied by the VBM method to explore the changes of gray matter volume in patients with first-episode untreated depression.Results Compared to healthy controls,the volume of gray matter in left middle tempral gyrus,right inslar lobe,left supeior occiptal gyrus and right dorsolteral supeior frontal gyrus were decresed in the first-episode untreated depression group(P<0.05,cluster size>45,AlphaSim correction),no region increased.Conclusion The brain regions with decreased gray matter volume in patients with first-episode untreated depression are mainly located in frontal lobe,temporal lobe,occipital lobe and insular lobe,indicating that the occurrence and development of depression is related to multiple brain regions.
作者
刘春梅
王春美
吴立山
周宏伟
邓方
高佩红
连亚慧
LIU Chunmei;WANG Chunmei;WU Lishan(Changchun Obstetrics-Gynecology Hospital,Changchun 130021,China)
出处
《中风与神经疾病杂志》
CAS
2021年第7期606-608,共3页
Journal of Apoplexy and Nervous Diseases
关键词
抑郁症
结构磁共振
基于体素的形态学方法
Depression
Structure magnetic resonance imaging
Voxel-based morphometry
