摘要
内侧前额叶皮层(medial prefrontal cortex,mPFC)接收多个皮层和皮层下区域的输入,并整合相关信息传送至其他皮层和皮层下脑区。mPFC在神经精神疾病相关事件如抑郁症、焦虑症、精神分裂症、阿尔茨海默病和帕金森病等,以及认知、社交和奖赏行为等神经精神活动过程中发挥重要作用。本文综述内侧前额叶皮层的神经环路联系在神经精神疾病中的作用及其分子机制,特别是近年来取得的研究进展。
The medial prefrontal cortex(mPFC)received input from multiple cortical and subcortical areas,and integrated relevant information to other cortical and subcortical areas.mPFC play an important role in neuropsychiatric events such as depression,anxiety,schizophrenia,Alzheimer s and Parkinson's disease,as well as in neuropsychiatric processes such as cognitive,social,and reward behaviors.This article reviews the role and molecular mechanism of the neural circuitry in the medial prefrontal cortex in neuropsychiatric diseases,especially the recent research progress.
作者
亓思豪
洪浩
QI Si-hao;HONG Hao(Dept of Pharmacology,School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2021年第6期745-748,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81773714,82071202)。
关键词
内侧前额叶皮层
神经精神疾病
神经环路
分子表达
medial prefrontal cortex
neuropsychiatric disorders
neural circuits
molecular expression
