摘要
在各种慢性肝损伤后,肝纤维化是生物体的一种自我修复性病理过程,并能引起肝硬化、肝癌等疾病。Wnt信号通路广泛存在于无脊椎动物和脊椎动物中,是一类在物种进化过程中高度保守的信号通路。许多研究已经证实Wnt信号通路与肝纤维化的发生发展有密切联系。主要从经典和非经典Wnt信号通路调控肝星状细胞、肝巨噬细胞、肝祖细胞的机制方面进行概述,为后续深入开展Wnt信号调控肝纤维化机制研究及探索可逆转肝纤维化的治疗靶点提供新思路。
Hepatic fibrosis(HF)is a self-healing pathological process after all kinds of chronic liver injuries and can cause diseases such as liver cirrhosis and liver cancer.The Wnt signaling pathway is highly conserved in species evolution and widely exists in invertebrates and vertebrates,and many studies have confirmed that the Wnt signaling pathway is closely associated with the development and progression of HF.This article reviews the mechanisms of the classical and non-classical Wnt signaling pathways in regulating hepatic stellate cells,hepatic macrophages,and hepatic progenitor cells,so as to provide new ideas for subsequent studies on the mechanism of the Wnt signaling pathway in regulating HF and further exploration of therapeutic targets that can reverse HF.
作者
范钦
李红俊
李晓霞
杨尹
陈海燕
成家茂
FAN Qin;LI Hongjun;LI Xiaoxia;YANG Yin;CHEN Haiyan;CHENG Jiamao(Department of Human Anatomy,Basic Medical College of Dali University,Dali,Yunnan 671000,China;Department of Ultrasound,School of Clinical Medicine,Dali University,Department of Ultrasound,The Fourth People’s Hospital of Yunnan Province,Dali,Yunnan 671000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第2期443-447,共5页
Journal of Clinical Hepatology
基金
2021年云南省地方本科高校基础研究联合专项资金面上项目(202101BA070001-101)
2022年云南省教育厅科学研究基金(2022Y809)
2021年云南省教育厅科学研究基金(2021J0382)
2017年度云南省自然科学基金高校联合基金(2017FH001-076)
云南省李云庆专家工作站项目(202005AF150014)
大理大学神经生物学创新团队项目(ZKLX2019108)。
关键词
肝硬化
WNT信号通路
肝星状细胞
枯否细胞
干细胞
Liver Cirrhosis
Wnt Signaling Pathway
Hepatic Stellate Cells
Kupffer Cells
Stem Cells
