摘要
肝纤维化是慢性肝病进展为肝硬化甚至肝细胞癌的病理基础。目前肝纤维化诊断的金标准为病理组织活检,但因其是有创性的,在临床应用中受到限制;影像学及血清学指标则因具有无创、操作简便、重复性好等优势,在临床广泛应用。目前肝纤维化尚无特异性治疗方案,主要通过病因治疗和抗肝纤维化治疗阻止或逆转肝纤维化。近年来,临床在肝纤维化的早期诊断及防治方面均取得一定进展,剪切波弹性成像、磁共振分子影像探针等影像技术具有精准诊断的潜力,但尚处于开发设计阶段,同时肝纤维化的治疗方法也尚不完善,因此未来深入研究肝纤维化的病因及早期诊治策略,可以为疾病的治疗提供新思路。
Liver fibrosis is the pathological basis for the development of chronic liver diseases to liver cirrhosis and even hepatocellular carcinoma.Currently,the gold standard for the diagnosis of liver fibrosis is pathological tissue biopsy,which is limited in clinical application due to the invasiveness.The imaging and serological indicators have the advantages of non-invasiveness,simple operation and good repeatability and they are widely used in clinic.At present,there is no specific treatment regimen for liver fibrosis,and etiological treatment and anti-liver fibrosis treatment are mainly used for the prevention or reversal.In recent years,some progress has been made in the early diagnosis and prevention and treatment of liver fibrosis.Imaging techniques such as shear wave elastography and magnetic resonance molecular imaging probe have the potential of precision diagnosis,but they are still in the development and design stage,and the treatment methods for liver fibrosis are still not perfect.Therefore,in-depth research on the etiology and early diagnosis and treatment strategy of liver fibrosis in the future can provide new ideas for the treatment.
作者
代术蓉
胥巧云
覃倩
DAI Shurong;XU Qiaoyun;QIN Qian(Health Management Center,General Practice Center,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《医学综述》
CAS
2023年第10期1994-1999,共6页
Medical Recapitulate
关键词
肝纤维化
早期诊断
预防
Liver fibrosis
Early diagnosis
Prevention
