摘要
目的:探讨国医大师徐经世所创升白汤联合重组人粒细胞刺激因子注射液(rhG-CSF)对于治疗晚期胃癌化疗后骨髓抑制的有效性。方法:采用随机分组的方法,将64例晚期胃癌的患者分为观察组和对照组各32例,对照组在化疗结束后给予rhG-CSF150μg皮下注射,观察组在化疗结束后皮下注射rhG-CSF的基础上口服升白汤。连续治疗21天为1个疗程。结果:骨髓抑制发生率:rhGCSF单药对照组和加用升白汤联合医治观察组患者均比治疗前降低(P均<0.05),加用升白汤联合观察组治疗后下降更加明显(P<0.05)。治疗后两组患者的中性粒细胞(N)、白细胞(WBC)、血红蛋白(Hb)和血小板计数(PLT)均较未治疗前升高(P均<0.05),加用升白汤联合观察组的相关血象指标升高则更为明显(P<0.05)。治疗后的生存质量:应用升白汤结合rhG-CSF的观察组优于rhGCSF单药对照组(P<0.05)。结论:对于晚期胃癌化疗后出现骨髓抑制患者,运用升白汤联合rhGCSF,可以更好地改善患者骨髓抑制的发生率,降低骨髓抑制导致的不良反应,进而提高患者的生活质量,值得临床进一步推广应用。
Objective:Gastric cancer is a common malignant tumor in the world.Chemotherapy is one of the main treatment methods.Because of its lack of specificity,chemotherapy drugs kill tumor cells while also causing damage to the patient’s body,often causing malignant vomiting,diarrhea,liver and kidney damage and other adverse reactions,myelosuppression is one of the most common side effects.To investigate the efficacy of Shengbai Decoction,be founded by National Medical Master Xu Jingshi,combined with rhG-CSF(recombinant human granulocyte stimulating factor injection)in the treatment of myelosuppression after chemotherapy for advanced gastric cancer.Methods:This study uses a randomized control method,64 patients with advanced gastric cancer were divided into observation group and control group,32 cases in each group.The control group was given a subcutaneous injection of rhG-CSF 150μg after chemotherapy,and the observation group was treated with oral administration of Shengbai Decoction on the basis of subcutaneous injection of rhG-CSF after chemotherapy.Continuous treatment of 21 days was 1 course of treatment.Results:Studies have shown that the incidence of myelosuppression in the control group and observation group after treatment was lower than before treatment(P<0.05),and the observation group dropped more significantly after treatment(P<0.05).The counts of neutrophils,white blood cells,hemoglobin and platelets in the control group and observation group after treatment were all higher than before treatment(P<0.05),and the related blood indicators in the observation group increased significantly(P<0.05).In addition,the quality of life of the observation group after treatment in this study was also better than that of the control group(P<0.05).Conclusion:In summary,for patients with myelosuppression after chemotherapy for advanced gastric cancer,the application of Shengbai Decoction created by Xu Jingshi combined with rhG-CSF can better improve the incidence of myelosuppression,reduce the adverse reactions caused by
作者
张明
李崇慧
Zhang Ming;Li Chonghui(Graduate School,Anhui University of Chinese Medicine,Hefei 230012,China;Department of Oncology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《亚太传统医药》
2022年第2期121-124,共4页
Asia-Pacific Traditional Medicine
关键词
晚期胃癌
骨髓抑制
升白汤
RHG-CSF
Advanced Gastric Cancer
Bone Marrow Suppression
Shengbai Decoction
rhG-CSF
