摘要
目的:研究多花黄精生品粗多糖与九蒸品粗多糖对1型糖尿病小鼠的降血糖作用,为多花黄精生品及九蒸品多糖的合理应用提供实验依据。方法:采用链脲佐菌素(STZ)50 mg/kg对小鼠多次小剂量腹腔注射诱导1型糖尿病模型,然后将造模成功小鼠随机分组。正常组和模型组给予0.9%氯化钠溶液,其余各组给予相应药物,连续灌胃4周后,检测相关指标。结果:与模型组比较,生品-高组与九蒸品-高组治疗4周时对1型糖尿病小鼠血糖均有显著抑制作用(P<0.05);两组血清中AST、ALT水平、肝脏指数、HK、PK酶活力均显著降低(P<0.05,P<0.01),能改善脂肪变性与肝糖原的储存能力。结论:多花黄精生品及九蒸品粗多糖均能调节1型糖尿病小鼠的血糖,这可能与抗氧化、调节糖脂代谢与肝脏功能等作用有关。
Objective:To study the hypoglycemic effect of crude polysaccharides from raw materials and nine-steamnine-bask processing Polygonati Rhizoma on type 1 diabetic mice,and to provide experimental basis for the appropriate use of nine-steam-nine-bask processing Polygonati Rhizoma.Methods:Multiple low-dose intraperitoneal injections(50 mg/kg STZ)were used to induce type 1 diabetes model.Then the model-building mice were randomly divided into different groups.Except for normal drinking normal saline in the normal group and model group,the remaining groups were given corresponding drugs.After 4 weeks,the relative indicators were tested.Results:Compared with the model group,the high-dose group of the crude and nine-steam-nine-bask processing Polygonati Rhizoma had an inhibitory effect on blood glucose(P<0.05);they could significantly reduce serum AST,ALT levels,liver index,HK,PK enzyme activity(P<0.05,P<0.01);they could improve steatosis and liver glycogen storage capacity.Conclusion:Raw materials and nine-steam-nine-bask processing Polygonati Rhizoma could both mediate blood glucose of type 1 diabetes.And it may be related to the regulation of glycolipid metabolism,antioxidant,liver function,etc.
作者
徐君
王秋丽
俞年军
彭代银
程鹤
邢丽花
周安
童小慧
吴振东
XU Jun;WANG Qiu-li;YU Nian-jun;PENG Dai-yin;CHENG He;XING Li-hua;ZHOU An;TONG Xiao-hui;WU Zhen-dong(School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Institute of Protection and Development of Traditional Chinese Medicine Resources,Anhui Academy of Chinese Medicine,Hefei 230012,China;Anhui Qingyang Jiuhua Traditional Chinese Medicine of Science and Technology Limited Company,Qingyang 242800,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2022年第1期391-394,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
安徽省科技重大专项项目(No.202003a07020011)
国家重点研发计划(No.2017YFC1701600,No.2017YFC1701602)。
关键词
多花黄精
多糖
九蒸品
生品
降血糖
1型糖尿病
机制
Polygonati Rhizoma
Polysaccharides
Nine-steam-nine-bask process
Raw materials
Hypoglycemic
Type 1 diabetes
Mechanism
