摘要
目的比较不同^(131)I给药方案治疗甲状腺功能亢进症(简称甲亢)的疗效及安全性。方法选取2019年8月至2020年8月某院甲亢患者120例,依据^(131)I给药方案分为多次组(n=60)和单次组(n=60),多次组给予多次小剂量^(131)I(50~80μCi/g,分2次口服,间隔3个月)治疗,单次组给予一次高剂量^(131)I(100~120μCi/g,一次性口服)治疗,比较两组疗效及安全性。结果多次组和单次组治疗3、6个月后游离三碘甲状腺氨酸(FT_(3))、游离四碘甲状腺氨酸(FT_(4))低于治疗前,多次组和单次组治疗3、6个月后促甲状腺激素(TSH)高于治疗前,多次组治疗3个月后FT_(3)、FT_(4)高于单次组,多次组治疗3个月后TSH低于单次组,差异有统计学意义(P<0.05),多次组和单次组治疗6个月后FT_(3)、FT_(4)、TSH基本相同(P>0.05);多次组和单次组治疗有效率基本相同(P>0.05);多次组暂时性甲状腺功能减退症(简称甲减)发生率低于单次组,差异有统计学意义(P<0.05)。结论单次高剂量和多次小剂量^(131)I治疗均可改善甲亢患者甲状腺功能,二者疗效相似,其中多次小剂量^(131)I治疗的给药方案具有较高的安全性,值得临床推广。
Objective To compare the efficacy and safety of different^(131)I administration regimens in the treatment of hyperthyroidism.Methods A total of 120 patients with hyperthyroidism in one hospital from August 2019 to August 2020 were selected,and they were divided into multiple group(n=60)and single group(n=60)according to1311 administration regimen.The multiple group was given multiple low-dose^(131)I(50-80μCi/g,orally divided into two times,at an interval of 3 months)treatment,and the single group was given one high-dose^(131)I(100-120μCi/g,orally taken once)treatment,the efficacy and safety of the two groups were compared.Results The free triiodothyronine(FT_(3))and free thyroxine four iodine(FF4)at 3 and 6 months after treatment in the multiple group and single group were lower than those in the before treatment,the thyroid stimulating hormone(TSH)at 3 and 6 months after treatment in the multiple group and single group were higher than those in the before treatment,the FT_(3) and FT_(4) at 3 months after treatment in the multiple group were higher than those in the single group,the TSH at 3 months after treatment in the multiple group was lower than that in the single group,the difference was statistically significant(P<0.05),and the FT_(3),FT_(4),TSH at 6 months after treatment in the multiple group and single group were basically the same(F>0.05).The effective rate in the multiple treatment group and single treatment group was basically the same(P>0.05).The incidence of temporary hypothyroidism in the multiple group was lower than that in the single group,the difference was statistically significant(P<0.05).Conclusions Both the single high dose and multiple low doses of 1311 can improve thyroid function in patients with hyperthyroidism,and the efficacy of the two treatments is similar.The administration regimen of multiple low doses of^(131)I has the high safety,it's worth for further clinical promotion.
作者
宋晏
陈正福
张学敏
SONG Yan;CHEN Zheng-fu;ZHANG Xue-min(Department of Nuclear Medicine,3201 Hospital,Hanzhong,Shaanxi 723000,China)
出处
《中国地方病防治》
CAS
2021年第5期406-408,共3页
Chinese Journal of Control of Endemic Diseases
