摘要
目的探讨腹腔镜下Roux-en-Y胃旁路手术(LRYGB)对肥胖T2DM患者血清IS和单核细胞趋化蛋白1(MCP-1)的影响。方法选取40例肥胖T2DM患者行LRYGB,ELISA法测定患者术前、术后6个月血清MCP-1水平,应用高胰岛素正葡萄糖钳夹实验评估IS,分析LRYGB对肥胖T2DM患者MCP-1和IS的影响。结果40例肥胖T2DM患者均无术中并发症发生及中转开腹。患者术后6个月HbA_(1)c、FPG、TC、TG及MCP-1水平较术前降低(P<0.05),FIns、葡萄糖代谢率及胰岛素抵抗指数较术前显著改善(P<0.05)。结论LRYGB可改善肥胖T2DM患者IS和MCP-1介导的炎症状态。
ObjectiveTo explore the effects of laparoscopic Roux-en-Y gastric bypass surgery on insulin sensitivity(IS)and serum monocyte chemotactic protein 1(MCP-1)in obesity patients with type 2 diabetes mellitus(T2 DM)by evaluating the changes of IS and MCP-1 before and after 6 months gastric bypass surgery.this study.MCP-1 was measured by ELISA methods before and after gastric bypass surgery.Hyperinsulinemic euglycemic clamp was applied to evaluate IS.The influence of LRYGB on MCP-1 and IS were analyzed in obesity patients with T2 DM.complications or conversion to open surgery.HbA_(1)c,FPG,TC,TG and MCP-1 levels were lower 6 months after surgery(P<0.05).The fasting insulin,Rd and IR index significantly decreased after surgery(P<0.05).ConclusionLRYGB could improve the IS and MCP-1 mediated inflammatory status in obesity patients with T2 DM.
作者
闫永鑫
赵鑫
周爱明
陈慧玉
王国凤
徐宁
郑之陈
惠媛
YAN Yongxin;ZHAO Xin;ZHOU Aiming(Department of General Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215006,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2022年第2期97-100,共4页
Chinese Journal of Diabetes
基金
连云港市卫生科技项目(局1402,201510)。
