摘要
目的探讨影响胃癌合并2型糖尿病(T2DM)病人术后糖尿病改善的相关因素。方法回顾性分析2013年1月至2016年7月第二军医大学附属长海医院162例胃癌合并T2DM病人临床及随访资料,包括性别、年龄、糖尿病病程、随访术后血糖变化及用药情况,肿瘤大小、分型、分期、浸润深度、淋巴转移情况,以及胃癌根治手术不同手术方式治疗(Bypass-:BillrothⅠ式吻合、近端胃切除;Bypass+:全胃或远端胃切除+Roux-en-Y吻合),采用CMH及秩和检验进行单因素分析,并对相关因素进行logistic回归分析。结果胃癌合并T2DM病人术后效果与病人年龄、肿瘤大小、手术方式及病程长短存在明显相关性。而与病人性别、术后血糖变化及用药情况、肿瘤分型、分期、浸润深度、淋巴转移情况指数无明显相关性。结论对于胃癌合并T2DM病人,Bypass+有助于改善胃癌术后病人血糖,特别是T2DM病程较短、年龄较小、肿瘤较小病人,以此提高术后短期内糖尿病改善。
Objective To investigate the improvment fators for patients of type 2 diabetes meliitus（T2DM） with gastric cancer after surgery. Methods The clinical data of 162 patients of gastric cancer associated with type 2 diabetes admitted from January 2013 to July 2016 in Department of Gastrointestinal Surgery, Changhai Hospital were collected, including gender, age, duration of diabetes, glucose, used drug and the remission of diabetes after different gastric cancer surgery （Bypass- ： Billroth-I, Proximal gastrectomy; Bypass ＋ ： Total, Distal gastrectomy ＋ Roux-en-Y anastomosis ）. One-way analysis of CMH rank-sum test was used, and logistic regression analysis was performed on the multiple factor. Results The postoperative results of patients with gastric carcinoma with T2DM were significantly correlated with the following factors ： age, type of surgery, tumor size and duration of T2DM, but not gender, glucose, used drug, tumor type, stage, depth of invasion, lymphatic metastasis. Conclusion For gastric cancer patients with T2DM, bypass ＋ help improve diabetes postoperatively, especially for T2DM short duration, smaller tumor and younger patients.
作者
庞涛
秦婴逸
史征
郑瑞
申晓军
聂明明
薛绪潮
毕建威
印慨
PANG Tao QIN Yin-yi SHI Zheng et al(Department of Gastrointestinal Surgery, Changhai Hospital, the Second Military Medical Univeristy of PLA, Shanghai 200433, Chin)
出处
《中国实用外科杂志》
CSCD
北大核心
2017年第2期175-178,共4页
Chinese Journal of Practical Surgery
关键词
胃癌
2型糖尿病
手术治疗
gastric cancer
type 2 diabetes mellitus
surgical treatment
