摘要
目的探讨人绒毛膜促性腺激素(HCG)日血清孕酮(P)水平与直径≥14 mm卵泡数比值(PFI)与体外受精-胚胎移植(IVF-ET)结局的关系。方法回顾性分析本中心进行IVF-ET治疗的206个周期患者的临床资料。按HCG日血清P水平与直径≥14 mm卵泡数的比值(PFI)分为A组(40例,PFI<0.05)、B组(105例,PFI 0.05~0.10)、C组(61例,PFI>0.10)。比较三组基本资料、临床结局,以及比较不同妊娠结局患者的基本资料、临床结局。结果A组、B组、C组年龄、不孕时间、基础FSH、HCG日内膜厚度、优胚数、移植胚胎数比较,差异无统计学意义(P>0.05);A组HCG日P水平显著低于B组、C组,直径≥14 mm卵泡数显著高于B组、C组,HCG日E_(2)水平显著高于C组,而且种植率52.38%、临床妊娠率75.00%均显著高于B组34.82%、54.29%及C组29.69%、47.54%,差异有统计学意义(P<0.05)。妊娠组与未妊娠组年龄、不孕时间、基础FSH、HCG日内膜厚、优胚数、移植胚胎数比较,差异无统计学意义(P>0.05);妊娠组HCG日P水平、PFI显著低于未妊娠组,HCG日E_(2)水平及直径≥14 mm卵泡数显著高于未妊娠组,差异有统计学意义(P<0.05)。结论HCG日PFI与IVF-ET具有关联,PFI<0.05的种植率、临床妊娠率较高,PFI水平的升高对种植率、临床妊娠率均有影响,即PFI水平过高对IVF-ET结局有一定的预测价值。
Objective To investigate the relationship between the daily serum progesterone(P)level of human chorionic gonadotropin(HCG)and the ratio of follicles with a diameter of≥14 mm(PFI)and the outcome of in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of 206 cycles of IVF-ET treatment at our center were retrospectively analyzed.According to the ratio of serum P level to the number of follicles with diameter≥14 mm on HCG day(PFI),the patients were divided into group A(40 cases,PFI<0.05),group B(105 cases,PFI 0.05~0.10)and group C(61 cases,PFI>0.10).The basic data and clinical outcomes of the three groups were compared,and the basic data and clinical outcomes of the patients with difffferent pregnancy outcomes were compared.Results There were no signifificant differences in age,infertility time,basal FSH,HCG daily intima thickness,number of optimal embryos and number of transplanted embryos in group A,group B and group C(P>0.05).The level of P on HCG day in group A was signifificantly lower than that in group B and C,the number of follicles with diameter≥14 mm in group A was signifificantly higher than that in group B and C,the level of E_(2) on HCG day was signifificantly higher than that in group C,and the implantation rate 52.38%and clinical pregnancy rate 75.00%were signifificantly higher than those in group B 34.82%and 54.29%and group C 29.69%and 47.54%.The difference was statistically signifificant(P<0.05).There were no signifificant differences in age,infertility time,basal FSH,HCG daily endometrial thickness,number of optimal embryos and number of transplanted embryos between pregnant group and non-pregnant group(P>0.05).P level and PFI in pregnant group were signifificantly lower than those in non-pregnant group,E_(2) level and number of follicles with diameter≥14 mm in pregnant group were signifificantly higher than those in non-pregnant group,the differences were statistically signifificant(P<0.05).Conclusion PFI on HCG day is correlated with IVF-ET.Implantation rate and clinic
作者
李慧
Li Hui(Department of Reproductive Medicine,Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,China)
出处
《实用妇科内分泌电子杂志》
2022年第2期13-16,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
体外受精-胚胎移植
人绒毛膜促性腺激素
孕酮
卵泡数
妊娠结局
In vitro fertilization-embryo transfer
Human chorionic gonadotropin
Progesterone
Follicle number
Pregnancy outcomes
