摘要
目的探讨体外受精-胚胎移植(IVF-ET)长方案促排卵助孕中HCG扳机次日血清β-HCG水平与临床结局的关系。方法回顾性分析在我中心接受IVF-ET长方案促排卵助孕患者的临床资料176例,按HCG扳机后次日血清β-HCG水平分为:A组(β-HCG≤50 IU/L) 5例,B组(50 IU/L <β-HCG≤100 IU/L) 49例,C组(100 IU/L <β-HCG≤150 IU/L) 49例,D组(150 IU/L <β-HCG≤200 IU/L) 34例、E组(β-HCG> 200 IU/L) 39例。分别比较各组的Gn使用天数和总量、HCG日E2水平、年龄、体质指数(BMI)、获卵率、MII卵率、正常受精率、优质胚胎率、可利用胚胎率、临床妊娠率、种植率。结果扳机次日血清β-HCG水平与BMI呈负相关(r=-0. 320,P <0. 01),A、B组BMI显著高于C、D、E组(P <0. 05),C、D、E三组间差异无统计学意义(P> 0. 05);扳机次日血清β-HCG水平与正常受精率呈正相关(r=0. 285,P <0. 01),A组正常受精率最低(P <0. 05),而E组正常受精率最高(P <0. 05),B、C、D三组间差异无统计学意义(P> 0. 05);获卵率、临床妊娠率随次日血清β-HCG水平升高有增加的趋势,组间比较无统计学差异(P>0. 05);各组Gn使用天数和总量、HCG日E2水平、患者的年龄、MII卵率、优质胚胎率、可利用胚胎率、种植率均不存在显著差异(P>0. 05)。结论 IVF-ET长方案促排卵周期中,HCG扳机次日血清β-HCG水平可能影响正常受精率,但不影响临床妊娠率。
Objective To investigate the relationship between serum β-HCG level and clinical outcomes of HCG trigger on the next day in long protocol ovulation induction and assisted pregnancy in vitro fertilization-embryo transfer( IVF-ET). Methods The clinical data of 176 cases receiving IVF-ET long protocol ovulation induction and assisted pregnancy in our center were retrospectively analyzed. According to the level of serum β-HCG on the next day after the trigger of HCG,the patients were divided into 5 groups: group A( β-HCG ≤50 IU/L,n = 5),group B( 50 IU/L < β-HCG≤100 IU/L,n = 49),group C( 100 IU/L < β-HCG ≤150 IU/L,n = 49),group D( 150 IU/L < β-HCG≤200 IU/L,n = 34)and group E( β-HCG > 200 IU/L,n = 39). The use duration and total consumption of gonadotropin,serum estradiol level at induced ovulation,age,body mass index( BMI),rate of oocytes retrieval,MII oocytes rate,normal fertilization rate,high-quality embryo rate,available embryo rate,clinical pregnancy rate and implantation rate were compared between the groups. Results The level of serum β-HCG was negatively correlated with BMI( r =-0. 320,P < 0. 01). The BMI of group A and B was higher than that of groups C,D and E( P < 0. 05). There was no significant difference among groups C,D and E( P > 0. 05). The level of serum β-HCG was positively correlated with normal fertilization rate( r = 0. 285,P < 0.01). The normal fertilization rate of group A was the lowest( P < 0. 05),while that of group E was the highest( P < 0. 05),and there was no significant difference among groups B,C and D( P > 0. 05). The rate of ovulation and clinical pregnancy increased with the increase of serum β-HCG level on the next day,but there was no statistical difference among groups( P> 0. 05). There were no significant differences in the use duration and total consumption of gonadotropin,serum estradiol level at induced ovulation,age,rate of MII oocyte,high quality embryo rate,available embryo rate and implantation rate among groups( P > 0. 05). Conclusion During the long IVF
作者
伍春蓉
冯兰青
黄惠英
王建
李超强
吴亚敏
WU Chunrong;FENG Lanqing;HUANG Huiying;WANG Jian;LI Caoqiang;WU Yaming(Department of Reproductive Center,Dongguan Tung Wah Hospital,Donguan 523110,China)
出处
《现代医院》
2020年第1期143-146,150,共5页
Modern Hospitals
基金
广东省东莞市社会一般科技项目(201605101095)
