摘要
目的探讨快走锻炼对改善子宫内膜异位症(EMs)促性腺激素释放激素激动剂(GnRH-α)相关骨丢失的临床效果。方法选取2019年1月至2020年4月新疆医科大学第一附属医院诊治的170例EMs患者作为研究对象。按照随机数字表法分为观察组和对照组,每组85例。最终,对照组76例完成研究,观察组74例完成研究。对照组给予亮丙瑞林治疗,观察组在对照组治疗基础上进行快走锻炼。比较两组的临床疗效､骨密度(BMD)､骨代谢指标及不良反应发生情况。结果两组治疗总有效率比较,差异无统计学意义(P>0.05)。治疗后,两组腰椎及股骨粗隆BMD较治疗前降低,骨钙素(BGP)､骨特异性碱性磷酸酶(BALP)等骨代谢指标水平较治疗前降低,β-I型胶原交联C-末端肽(β-CTX)水平较治疗前升高,差异具有统计学意义(P<0.05);但观察组治疗后腰椎及股骨粗隆BMD､BGP､BALP水平高于对照组,β-CTX水平低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论对于接受GnRH-α治疗的EMs患者,进行快走锻炼能够改善GnRH-a相关骨丢失,减少不良反应。
Objective To study the effect of fast walking exercise on gonadotropin releasing hormone-α(GnRH-α)therapy-related bone loss in patients with endometriosis(EMs).Methods A total of 170 EMs pa-tients treated in the First Hospital Affiliated to Xinjiang Medical University from January 2019 to April 2020 were selected as the research object.According to random number table method,they were divided into observa-tion group and control group,85 cases in each group.Finally,76 cases in the control group and 74 cases in the observation group completed the study.The control group was given leprorelin treatment,and the observation group was given fast walking exercise on the basis of treatment in the control group.The clinical efficacy,bone mineral density(BMD),bone metabolism indices and adverse reactions in the two groups were compared.Results There was no significant difference in the total effective rate between the two groups(P>0.05).Compared with before treatment,BMD of lumbar vertebrae and femoral trochanter decreased,the levels of bone metabolism indexes such as bone glaprotein(BGP),bone specific alkaline phosphatase(BALP)and higher level ofβ-type I collagen carboxy-terminal peptide(β-CTX)after treatment increased(P<0.05).However,BMD,BGP and BALP levels of lumbar vertebrae and femoral trochanter in the observation group were higher than those in the control group,whileβ-CTX levels were lower than those in the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusions For EMs patients receiving GnRH-αthearpy,fast walking exercise can improve GnRH-αrelated bone loss and reduce adverse reactions,which is worthy of clinical recommendation.
作者
赵玲赤
马艳红
何艳
ZHAO Lingchi;MA Yanhong;HE Yan(No.3 Department of Gynecology,the First Hospital Affiliated to Xinjiang Medical University,Urumqi 830054,Xinjiang,China;Gynecology Center,the First Hospital Affiliated to Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
出处
《中国性科学》
2022年第2期71-74,共4页
Chinese Journal of Human Sexuality
基金
新疆维吾尔自治区自然科学课题基金(2016D01C283)。
