摘要
目的:探讨促性腺激素释放激素(GnRH-α)联合腹腔镜治疗对子宫内膜异位症(EMT)患者视黄醇结合蛋白4(RBP4)、恶性肿瘤特异性生长因子(TSGF)、血管生成素受体2(Tie-2)水平影响。方法:随机数字表法将300例子宫内膜异位症患者分为GnRH-α联合腹腔镜治疗组(联合组,150例)和单独腹腔镜治疗组(腹腔镜组,150例)。对比两组疗效和安全性、治疗前后RBP4、TSGF、Tie-2水平差异。结果:治疗后联合组有效率(94.7%)高于对照组(74.7%),复发率(2.0%)低于对照组(18.0%),RBP4(13.82±2.03μg/L)、TSGF(40.36±4.99U/L)、Tie-2(23.04±3.06mg/L)低于对照组(18.02±3.02μg/L、55.23±7.27U/L、33.23±4.09mg/L)(均P<0.05)。不良反应发生率联合组(2.0%)与腹腔镜组(0.0%)无差异(P>0.05)。结论:GnRH-α联合腹腔镜可显著降低EMT患者RBP4、TSGF、Tie-2水平,减少复发,效果优于单独腹腔镜治疗。
Objective:To investigate the influence of gonadotropin releasing hormone(GnRH-alpha)combined with laparoscopy for treating women with endometriosis on their levels of retinol binding protein 4(RBP4),tumor specific growth factor(TSGF),and angiopoietin receptor 2(Tie-2).Method:300 women with endometriosis were divided into group A(150 women treated by GnRH-alpha combined with laparoscopic)and group B(150 women treated by laparoscopic treatment only).The efficacy,safety,and the RBP4,TSGF and Tie-2 levels before and after treatment of women were compared between the two groups.Results:The effective rate(94.7%)of women in group A was significant higher than that(74.7%)of women in group B.The recurrence rate,and the levels of RBP4,TSGF and Tie 2 of women in group A were 2.0%,13.82±2.03 g/L,40.36±4.99U/L,and 23.04±3.06mg/L,respectively,which were significant lower than those(18.0%,18.02±3.02 g/L,55.23±7.27U/L,33.23±4.09mg/L,respectively)of women in group B(all P<0.05).There was no significant difference in the incidence of adverse reaction(2.0%vs.0.0%)of women between the two groups(P>0.05).Conclusion:GnRH-alpha combined with laparoscopy for treating women with endometriosis can significantly reduce their levels of RBP4,TSGF and Tie-2,and reduce the recurrence of endometriosis,which’s effect is better than that of laparoscopy used alone.
作者
王泽琴
段洁
WANG Zeqin;DUAN Jie(The Ninth Hospital of Wuhan, Hubei Province, 430081)
出处
《中国计划生育学杂志》
2020年第8期1197-1200,共4页
Chinese Journal of Family Planning
