摘要
目的探讨不同青霉素治疗妊娠期梅毒对产妇外周血肿瘤坏死因子-α(TNF-α)､白介素-2(IL-2)､白介素-4(IL-4)及新生儿预后的影响。方法选取西北妇女儿童医院2019年3月至2021年3月收治的118例妊娠期梅毒孕妇作为研究对象,采用随机数字表法分为观察组与对照组,各59例。对照组入院后以普鲁卡因青霉素治疗,观察组入院后以苄星青霉素治疗。比较两组产妇及新生儿的妊娠结局,比较两组产妇治疗前后外周血TNF-α､IL-2､IL-4水平,比较两组产妇治疗后血清快速血浆反应素试验(RPR)､梅毒螺旋体血凝试验(TPHA)滴度阴性率。结果观察组正常妊娠产妇占比显著高于对照组,而早产､流产发生率显著低于对照组,差异具有统计学意义(P<0.05);两组死胎发生率比较,差异无统计学意义(P>0.05)。观察组正常新生儿占比显著高于对照组,而低体重儿､新生儿窒息､新生儿先天性梅毒发生率显著低于对照组,差异具有统计学意义(P<0.05);两组新生儿死亡发生率比较,差异无统计学意义(P>0.05)。两组治疗前TNF-α､IL-2､IL-4水平比较,差异无统计学意义(P>0.05);两组治疗后TNF-α､IL-2､IL-4水平均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组治疗后血清RPR､TPHA滴度阴性率显著高于对照组,差异具有统计学意义(P<0.05)。结论苄星青霉素治疗妊娠期梅毒能够改善产妇妊娠结局及新生儿预后,还能降低产妇外周血TNF-α､IL-2､IL-4水平,提高血清RPR､TPHA滴度阴性率。
Objective To investigate the effects of different penicillin treatment on peripheral blood tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),interleukin-4(IL-4)and neonatal prognosis of pregnant syphilis.Methods A total of 118 cases of pregnant women with syphilis admitted to Northwest Women′s and Children′s Hospital from March 2019 to March 2021 were selected and divided into observation group and control group by random number table method,with 59 cases in each group.The control group was treated with procaine penicillin and the observation group was treated with benzathine penicillin.The maternal and newborn pregnancy outcomes of the two groups were compared,the levels of TNF-α,IL-2 and IL-4 in peripheral blood of the two groups were compared before and after treatment,and the negative rate of serum rapid plasma reagin(RPR)and treponema pallidum hemagglutination test(TPHA)after treatment was compared between the two groups.Results The proportion of normal pregnant women in the observation group was significantly higher than that in the control group,while the incidence of premature birth and abortion was significantly lower than that in the control group,with statistical significance(P<0.05).There was no significant difference in the in-cidence of stillbirth between the two groups(P>0.05).The proportion of normal neonates in the observation group was significantly higher than that in the control group,while the incidence of low birth weight,neonatal asphyxia and neonatal congenital syphilis was significantly lower than that in the control group,and the differ-ence was statistically significant(P<0.05).There was no significant difference in the incidence of neonatal death between the two groups(P>0.05).There were no significant differences in TNF-α,IL-2 and IL-4 levels between two groups before treatment(P>0.05).The levels of TNF-α,IL-2 and IL-4 in two groups after treat-ment were lower than before,and the observation group was lower than the control group,the difference was sta-tistically significant
作者
郭育
刘娟
张春利
张俊梅
蒋艳丽
GUO Yu;LIU Juan;ZHANG Chunli;ZHANG Junmei;JIANG Yanli(Department of Gynecology and Obstetrics,Northwest Women′s and Children′s Hospital,Xi′an 710061,Shaanxi,China)
出处
《中国性科学》
2022年第2期59-63,共5页
Chinese Journal of Human Sexuality
基金
陕西省科学技术研究发展计划项目(2010K15-06-01)。
关键词
妊娠期
梅毒
普鲁卡因青霉素
苄星青霉素
妊娠结局
Pregnancy
Syphilis
Procaine penicillin
Benzathine penicillin
Pregnancy outcomes
