摘要
目的探讨中重度牙周炎合并银屑病与代谢综合征(MS)各组分的相关性。方法选取中重度牙周炎患者50例(中重度牙周炎组)、银屑病患者50例(银屑病组)、中重度牙周炎合并银屑病患者50例(中重度牙周炎合并银屑病组),以健康体检者50名作为正常对照组。检测所有对象的血压、糖化血红蛋白(HbA1c)、血糖(Glu)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。采用多因素Logistic回归分析评估疾病发生的危险因素。结果中重度牙周炎组、银屑病组TC和LDL-C水平高于正常对照组(P<0.05)。中重度牙周炎合并银屑病组TG、LDL-C、TC和HbA1c水平高于中重度牙周炎组(P<0.05),TG、LDL-C、TC水平高于银屑病组(P<0.05)。中重度牙周炎合并银屑病组TG、LDL-C、TC、Glu和HbA_(1c)显著高于正常对照组(P<0.01)。多因素Logistic回归分析结果显示,LDL-C升高是中重度牙周炎发生的危险因素[比值比(OR)=1.873,95%可信区间(CI)为1.113~3.154],TC升高是银屑病发生的危险因素(OR=1.527,95%CI为1.012~2.304);TC、HbA1c升高是中重度牙周炎合并银屑病发生的危险因素(OR值分别为2.728、3.108,95%CI分别为1.572~4.732、1.283~7.533)。结论中重度牙周炎合并银屑病患者糖、脂代谢紊乱情况更为严重,TC、HbA_(1c)升高是中重度牙周炎合并银屑病发生的危险因素。
Objective To investigate the correlation between metabolic syndrome(MS)and moderateto-severe periodontitis complicated with psoriasis.Methods A total of 50 patients with moderate-to-severe periodontitis,50 patients with psoriasis and 50 patients with moderate-to-severe periodontitis complicated with psoriasis were enrolled.Totally,50 healthy subjects were enrolled as control group.Blood pressure,glycated hemoglobin A_(1c)(HbA_(1c)),glucose(Glu),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were determined.Multivariate Logistic regression analysis was used to assess the risk factors for disease development in each group.Results TC and LDL-C in moderate-to-severe periodontitis group and psoriasis group were higher than those in control group(P<0.05).TG,LDL-C,TC and HbA1c were higher in moderate-to-severe periodontitis complicated with psoriasis group than those in moderate-to-severe periodontitis group(P<0.05),and TG,LDL-C and TC were higher than those in psoriasis group(P<0.05).In moderate-to-severe periodontitis complicated with psoriasis group,TG,LDL-C,TC,Glu and HbA_(1c) were higher than those in control group(P<0.01).Multivariate Logistic regression analysis showed that elevated LDL-C was a risk factor for the development of moderate-to-severe periodontitis[odds ratio(OR)=1.873,95%confidence interval(CI)1.113-3.154],elevated TC was a risk factor for the development of psoriasis(OR=1.527,95%CI 1.012-2.304),and elevated TC and HbA_(1c) were risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis(OR=2.728 and 3.108,95%CI 1.572-4.732 and 1.283-7.533,respectively).Conclusions Patients with moderate-to-severe periodontitis complicated with psoriasis show more significant disorders of MS-related components than patients with periodontitis or psoriasis alone,and elevated TC and HbA_(1c) are risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis.
作者
陈梁
李琳
李霞
张岩
吴炯睿
高益鸣
CHEN Liang;LI Lin;LI Xia;ZHANG Yan;WU Jiongrui;GAO Yiming(Department of Stomatology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Dermatology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《检验医学》
CAS
2022年第2期126-129,共4页
Laboratory Medicine
关键词
代谢综合征
牙周炎
银屑病
Metabolic syndrome
Periodontitis
Psoriasis
