摘要
目的观察氯吡格雷联合阿司匹林治疗急性脑梗死的临床效果与安全性。方法选取2018年3月-2020年2月文山州中医医院收治的急性脑梗死患者96例,按照住院单双号分为联合组和对照组,每组48例。在常规治疗基础上,对照组予阿司匹林肠溶片治疗,联合组在对照组基础上加用硫酸氢氯吡格雷片治疗。比较2组治疗效果,治疗前后神经功能评分、生活质量评分及不良反应。结果联合组患者治疗总有效率为87.50%,高于对照组的66.67%(χ^(2)=5.897,P=0.015);治疗2个疗程后,2组美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低,生理、心理及社会方面评分均较治疗前升高,且联合组降低或升高幅度大于对照组(P均<0.01);2组不良反应总发生率(6.25%vs. 4.17%)比较差异无统计学意义(χ^(2)=0.211,P=0.646)。结论急性脑梗死采用氯吡格雷联合阿司匹林治疗效果显著,有助于改善患者神经功能、提高其生活质量,且不良反应发生风险低,值得临床推广应用。
Objective To observe the clinical effect and safety of clopidogrel combined with aspirin in the treatment of acute cerebral infarction.Methods Ninety-six patients with acute cerebral infarction treated by Wenshan Hospital of Traditional Chinese Medicine from March 2018 to February 2020 were selected, they were divided into combined group and control group,with 48 cases in each group. On the basis of routine treatment, the control group was treated with aspirin enteric coated tablets,and the combined group was treated with clopidogrel bisulfate tablets on the basis of the control group. The treatment effect,neurological function score and quality of life score before and after treatment, as well as the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the combined group was 87. 50%, higher than 66. 67% of the control group(χ^(2)=5. 897,P= 0. 015). After two courses of treatment, the scores of NIHSS in the two groups were lower than those before treatment, and the scores of physiological, psychological and social aspects were higher than those before treatment, and the decrease or increase in the combined group was greater than that in the control group(P< 0. 01). There was no significant difference in the total incidence of adverse reactions between the two groups(6. 25% vs. 4. 17%)(χ^(2)=0. 211,P=0. 646).Conclusion Clopidogrel combined with aspirin is effective in the treatment of acute cerebral infarction, which helps to improve patients′ neurological function and improve their quality of life, and the risk of adverse reactions is low, which is worthy of clinical application.
作者
杨寿宇
YANG Shouyu(Department of Encephalopathy,Wenshan Hospital of Traditional Chinese Medicine,Wenshan 663000,China)
出处
《临床合理用药杂志》
2022年第1期11-13,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
急性脑梗死
氯吡格雷
阿司匹林
治疗效果
安全性
Acute cerebral infarction
Clopidogrel
Aspirin
Therapeutic effect
Security
