摘要
目的观察不同剂量氯吡格雷联合阿司匹林或单用阿司匹林治疗急性脑梗死的临床效果。方法选取338例脑梗死患者,随机分为联合负荷剂量组(104例)、联合常规剂量组(116例)和阿司匹林负荷剂量组(118例),比较各组总有效率及美国国立卫生研究院卒中量表(NIHSS)评分改善情况。结果联合负荷剂量组总有效率88.5%,高于联合常规剂量组的72.4%和阿司匹林负荷剂量组的67.7%,差异有统计学意义(P<0.05)。出院时再次应用NIHSS进行评估,3组NIHSS评分均低于治疗前,且联合负荷剂量组与联合常规剂量组、阿司匹林负荷剂量组比较差异有统计学意义(P<0.05),3组不良反应差异无统计学意义(P>0.05)。结论负荷剂量阿司匹林联合氯吡格雷治疗脑梗死临床效果满意,可提高患者预后质量。
Objective To integrative clinical efficacy of load dose clopidogrel combined with aspirin in treatment of patients with cerebral infarction. Methods 338 patients with cerebral infarction were randomly divided into three groups:the group with loading dose clopidogrel and aspirin (104 cases),the group with common dose clopidogrel and aspirin (116 cases) and the group with loading dose aspirin (118 cases).The NHISS score,clinical efficacy and adverse drug reactions between groups were compared. Results After the treatment,the NHISS score of three groups were significantly decreased,and the NHISS score of loading dose clopidogrel and aspirin group was significantly lower than the other groups( P < 0.05).The total effective rate of loading dose clopidogrel and aspirin group was significantly higher than the other groups( P < 0.05),while adverse drug reactions rate of three groups was no significantly difference. Conclusion The treatment of load dose clopidogrel combined with aspirin for cerebral infarction has a curative effect,and it is worth for clinical promotion.
作者
张继中
郑远征
李珂
刘崇
ZHANG Jizhong;ZENG Yuanzheng;LI Ke;LIU Chong(Department of Neurology,the First Hospital of Nanyang,Nanyang473000,China)
出处
《中国实用神经疾病杂志》
2019年第3期281-287,共7页
Chinese Journal of Practical Nervous Diseases
关键词
脑梗死
负荷剂量
氯吡格雷
阿司匹林
抗血小板聚集剂
Cerebral infarction
Loading dose
Clopidogrel
Aspirin
Antiplatelet aggregation agent
