摘要
目的探讨氯吡格雷联合阿司匹林治疗急性轻度脑梗死的临床疗效及安全性。方法选取2020年1月至2021年12月当阳市人民医院收治的80例急性轻度脑梗死患者作为研究对象,按照随机数字表法分为对照组与观察组,各40例。对照组给予阿司匹林治疗,观察组在对照组基础上联合氯吡格雷治疗。比较两组临床疗效、神经功能缺损程度、日常生活能力、炎症因子水平、血液流变学指标、血管内皮功能、不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组Barthel指数评分均高于治疗前,美国国立卫生研究院卒中量表(NIHSS)评分均低于治疗前,且观察组Barthel指数评分高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-6、肿瘤坏死因子-α、C反应蛋白、血小板凝聚率、血浆黏度、全血黏度水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组一氧化氮(NO)、降钙素基因相关肽(CGRP)水平均高于治疗前,内皮素(ET)水平均低于治疗前,且观察组NO、CGRP水平均高于对照组,ET水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论氯吡格雷联合阿司匹林治疗急性轻度脑梗死,整体治疗效果确切且安全,能显著改善患者神经功能缺损,减轻炎症反应,并调节血液流变学,预后理想。
Objective To investigate the clinical efficacy and safety of clopidogrel combined with aspirin in the treatment of acute mild cerebral infarction.Methods A total of 80 patients with acute mild cerebral infarction admitted to the People's Hospital of Dangyang City from January 2020 to December 2021 were selected as the research subjects,and they were divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group was treated with aspirin,and the observation group was treated with clopidogrel on the basis of the control group.The clinical efficacy,the degree of neurological impairment,the ability of daily living,the level of in-flammatory factors,the indexes of hemorheology,vascular endothelial function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,the difference was statistically signifi-cant(P<0.05).After treatment,the scores of Barthel index of the two groups were higher than before treatment,the scores of National Institutes of Health stroke scale(NIHSS)were lower than before treatment,and the Barthel index score in the observation group was higher than that in the con-trol group,the NIHSS score was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the lev-els of interleukin-6,tumor necrosis factor-α,C-reactive protein,platelet aggregation rate,plasma viscosity and blood viscosity of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Af-ter treatment,the levels of nitric oxide(NO)and calcitonin gene-related peptide(CGRP)of the two groups were higher than before treatment,the en-dothelin(ET)level of the two groups was lower than before treatment,and the levels of NO,CGRP in the observation group were higher than those in the control group,
作者
谢丽萍
夏青
史章强
XIE Liping;XIA Qing;SHI Zhangqiang(Department of Neurology,People's Hospital of Dangyang City,Yichang,Hubei,444100,China;Department of General Medicine,People's Hospital of Dangyang City,Yichang,Hubei,444100,China)
出处
《当代医学》
2024年第6期40-43,共4页
Contemporary Medicine
