摘要
目的探讨结肠癌合并糖尿病患者血糖水平与可溶性细胞间黏附分子-1(sICAM-1)、C反应蛋白(CRP)的关系及术后感染的影响因素。方法根据是否出现术后感染将168例结肠癌合并糖尿病患者分为观察组(n=68,术后感染)和对照组(n=100,术后无感染)。比较两组患者的围手术期(术前、术后1天、术后7天)血糖水平,比较术后7天两组患者的外周血辅助性T细胞17(Th17)和调节性T细胞(Treg)水平。分析围手术期血糖水平与s ICAM-1、CRP水平的相关性,采用Logistic回归模型分析结肠癌合并糖尿病患者术后感染的影响因素。结果术后1天和术后7天,两组患者的sICAM-1、CRP水平均高于本组术前,且观察组患者的s ICAM-1、CRP水平均高于对照组,差异均有统计学意义(P<0.05);术后7天,观察组患者的血糖水平高于对照组,差异有统计学意义(P<0.05)。术后7天,观察组患者的外周血Th17/CD4^(+)、Th17/Treg均明显高于对照组,Treg/CD4^(+)明显低于对照组,差异均有统计学意义(P<0.01)。两组患者的围手术期血糖水平均与s ICAM-1、CRP水平呈正相关(P<0.05)。Logistic回归分析结果显示,sICAM-1、CRP水平及血糖控制情况均是结肠癌合并糖尿病患者术后感染的独立影响因素(P<0.01)。结论结肠癌合并糖尿病患者的围手术期血糖水平与sICAM-1、CRP水平均呈正相关,s ICAM-1、CRP水平及血糖控制情况均是结肠癌合并糖尿病患者术后感染的独立影响因素,控制炎性因子水平及血糖水平有利于降低患者的术后感染风险。
Objective To explore the relationship between blood glucose level and soluble intercellular adhesion molecule-1(sICAM-1)and C-reactive protein(CRP)in colon cancer patients complicated with diabetes mellitus and influencing factors of postoperative infection.Method According to whether there is postoperative infection,168 patients with colon cancer complicated with diabetes mellitus were divided into observation group(n=68,with postoperative infection)and control group(n=100,without postoperative infection).The perioperative(preoperative,1 day after operation and 7 days after operation)blood glucose levels of the two groups were compared,and the levels of peripheral blood T helper cell 17(Th17)and regulatory T cell(Treg)of the two groups were compared 7 days after operation.The relationship between the blood glucose level and sICAM-1 and CRP was analyzed.Logistic regression model was used to analyze the influencing factors of postoperative infection in patients with colon cancer complicated with diabetes mellitus.Result One day and 7 days after operation,the levels of sICAM-1 and CRP in the two groups were significantly higher than those before operation,and the levels of sICAM-1 and CRP in the observation group were higher than those in the control group(P<0.05).Seven days after operation,the blood glucose level in the observation group was significantly higher than that in the control group(P<0.05).Seven days after operation,Th17/CD4^(+)and Th17/Treg in peripheral blood of the observation group were significantly higher than those of the control group,while Treg/CD4^(+)was significantly lower than that of the control group(P<0.01).The perioperative blood glucose of the two groups was positively correlated with the levels of sICAM-1 and CRP(P<0.05).Logistic regression analysis showed that sICAM-1,CRP levels and blood glucose control were independent factors affecting postoperative infection of patients with colon cancer complicated with diabetes mellitus(P<0.01).Conclusion The perioperative blood glucose level of
作者
楚英娜
宋利革
李蕾
孙玲
康志强
CHU Yingna;SONG Lige;LI Lei;SUN Ling;KANG Zhiqiang(Department of Endocrinology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,He’nan,China)
出处
《癌症进展》
2022年第1期38-41,共4页
Oncology Progress
关键词
结肠癌
糖尿病
术后感染
血糖
可溶性细胞间黏附分子-1
C反应蛋白
colon cancer
diabetes mellitus
postoperative infection
blood glucose
soluble intercellular adhesion molecule-1
C-reactive protein
