摘要
目的:对比微镜夹闭术与血管内介入栓塞术在脑动脉瘤治疗中的作用。方法:对泰兴市人民医院神经外科收治的脑动脉瘤患者进行研究,均于2018年1月-2020年12月就诊,根据随机数字表法分组,对照组和观察组各15例。对照组应用显微镜夹闭术,观察组应用血管内介入栓塞术,比较两组治疗总有效率、治疗前后血清指标和并发症发生率。结果:观察组总有效率为93.33%,高于对照组的53.33%,差异有统计学意义(P<0.05);观察组并发症发生率为6.67%,低于对照组的46.67%,差异有统计学意义(P<0.05);两组治疗前血清指标对比,差异无统计学意义(P>0.05),观察组治疗后血管内皮生长因子(VEGF)为(223.12±28.78)pg/ml,可溶性细胞间黏附分子-1(sICAM-1)为(183.21±14.69)ng/ml,血清核因子-κB(NF-κB)为(15.18±2.32)μmol/ml,低于对照组的(260.72±30.15)pg/ml、(210.36±18.12)ng/ml和(20.16±2.54)μmol/ml,差异有统计学意义(P<0.05)。结论:在脑动脉瘤治疗中应用血管内介入栓塞术,可获得理想的疾病治疗效果,改善血清指标作用明显,防范并发症作用明显,存在广泛应用价值。
Objective:To compare the effect of microscope clipping and intravascular interventional embolization in the treatment of cerebral aneurysm.Method:Patients with cerebral aneurysms admitted to the Neurosurgery Department of Taixing People’s Hospital from January 2018 to December 2020 were studied.According to random number table method,there were 15 cases in the control group and 15 cases in the observation group.The control group was treated with microscope clipping,and the observation group was treated with intravascular interventional embolization.The total effective rate,serum index and complication rate before and after treatment were compared.Result:The total effective rate of the observation group was 93.33%,which was higher than 53.33% of the control group,and the difference was statistically significant (P<0.05);the incidence of complications in the observation group was 6.67%,which was lower than 46.67% in the control group (P<0.05).There were no differences in serum indexes before treatment (P>0.05),VEGF in observation group was (223.12±28.78) pg/ml,sICAM-1 was (183.21±14.69) ng/ml,NF-κB was (15.18±2.32) μmol/ml,lower than (260.72±30.15) pg/ml,(210.36±18.12) ng/ml and (20.16±2.54) μmol/ml in the control group,the differences were statistically significant (P<0.05).Conclusion:The application of intravascular embolization in the treatment of cerebral aneurysm can achieve ideal therapeutic effect,improve serum index and prevent complications.There is a wide range of application value.
作者
蒋峰
JIANG Feng(Taixing People’s Hospital,Taixing 225400,China)
出处
《中外医学研究》
2021年第35期67-70,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
显微镜夹闭术
血管内介入栓塞术
脑动脉瘤
临床疗效
血清指标
并发症
Microscope occlusion
Intravascular interventional embolization
Cerebral aneurysm
Clinical efficacy
Serum index
Complications
