摘要
目的探讨血管内介入栓塞术对脑动脉瘤病人术后康复及血清肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法选取2014年5月—2017年4月达州市中心医院收治的96例脑动脉瘤病人,按照不同术式分为观察组与对照组,各48例。观察组行血内管介入栓塞术,对照组行传统开颅夹闭术。比较两组术后并发症发生率、住院时间,观察两组术前及术后血清相关因子(TNF-α、sICAM-1)水平、神经功能缺损评分(NDS)变化,术后随访3个月,统计两组预后情况。结果观察组术后并发症发生率为4.17%(2/48),低于对照组的16.67%(8/48),住院时间短于对照组,差异均有统计学意义(P<0.05)。术后7 d,观察组血清TNF-α、sICAM-1均低于对照组,差异有统计学意义(P<0.05);术后1个月,两组NDS评分均有所降低,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组术后3个月预后情况优于对照组,差异有统计学意义(P<0.05)。结论脑动脉瘤病人采用血管内介入栓塞术治疗,可有效降低术后并发症发生率、缩短住院时间,且有利于改善病人血清TNF-α、sICAM-1水平及神经功能,进而有助于改善预后。
Objective To investigate the effect of intravascular embolization on postoperative rehabilitation and serum tumor necrosis factor-α(TNF-α),soluble intercellular adhesion molecule-1(sICAM-1)in patients with cerebral aneurysm.Methods Ninety-six patients with cerebral aneurysm in Dazhou Central Hospital hospital from May 2014 to April 2017 were divided into observation group and control group according to different surgical procedures,with 48 cases each group.The observation group was treated with blood endothelium interventional embolization,the control group was treated with conventional craniotomy.Postoperative complication,hospital stay,serum-related factors(TNF-α,sICAM-1)levels,and neurological function(NDS)score were compared preoperativen and postoperative between two groups.Patients were followed up for 3 months,and the prognosis were statistically analyzed.Results The incidence of postoperative complications of the observation group was lower than that in the control group(4.17% vs 16.67%,P<0.05).The hospitalization time was shorter than that of the control group(P<0.05).At 7 days after operation,the levels of serum TNF-αand s ICAM-1 of the observation group were lower than those of the control group(P<0.05).At 1 month after operation,the NDS scores of the two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The prognosis of the observation group was better than that of the control group at 3 months postoperatively,the difference was statistically significant(P<0.05).Conclusion Given cerebral aneurysm patients intravascular interventional embolization treatment could effectively reduce the incidence of postoperative complications,shorten hospital stay,improve serum TNF-α,sICAM-1 levels and neurological function,and thus help to improve the prognosis.
作者
邓功建
冉娅娅
刘谊
陈泰山
DENG Gongjian;RAN Yaya;LIU Yi;CHEN Taishan(Dazhou Central Hospital,Dazhou 635000,Sichuan,China)
出处
《中西医结合心脑血管病杂志》
2019年第21期3419-3422,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
四川省卫生厅科研基金项目(No.140060)
关键词
脑动脉瘤
血管内介入栓塞术
肿瘤坏死因子-α
可溶性细胞间黏附分子-1
预后
神经功能缺损
cerebral aneurysm
vascular interventional embolization
tumor necrosis factor-α
soluble intercellular adhesion molecule-1
prognosis
neurological deficit score
